DB ,)<1;HBIRZXaph`rx0PhH<\Xp4T!P+X6:A<ItP|Za,j q$y X`tHtth< 8 *X18CJ4QZ|axhrz$0H8 <ʘt0lLt0 $#@(19@JQ,X@ahs\xx8PPh<<D`$D`  *18@J`QhXbipzlpx`($XXД,88l t|  T)L59@(JQXcPj\qPxl<ȸ  X"p)0:@$JQXcjqxXhtш؜Ld $ .2`9t@K,R<Y\b<hvhyh0HdȤL`p(h $($08(@HPXp`tj?jc Atlas.dataa%&$%)Quantum 2G:Pathology:V6 Atlas:Atlas.data"#>>0,kk6Le}#e>0f!"g"#{>p,jk6L#>p!""#>ð,jk6L&>ð$%%&%&+Vy yxDG2MA/CNS-1 Normal neuron5f@S  DGM>  &&,. :A-112-89aRenal;T-77100 M-72030Gross A-112-89-02!.Diagnosis: Nodular hyperplasia of the prostate Close-up viewf@ nI DD`Ff@+f@,Sƀf@kf@Gf@ef@ǀf@ S f@ s($P( ˏ{($\($Tˏ($h($`ˏ ($t($lˏ($($x m@BJxxˏ($($1X ($($1X($($1X ($($M: ($($_(x ($($($(${($($ ($($ (%($(%(% (%(%{(%((% m@BJ  m@BJ!aab2bdbccDccdRdde@eefTffDGRM!>  &&,. :A-111-58 RenalT-71010 M-52000oGross A-111-58-01 2Diagnosis: Arteriolonephrosclerosis of the kidneysuThe external surface of the kidney, after the renal capsule has been stripped off, showing "scotch grain" appearance. /E@?#(@RU3!Dl'$<0nfF3G)aĀ/ǀˀw)΀\ӀԀՀր׀؀#(݀  ' Ld    y~MK.: !" #$%&'()*+,-.012345689:<=L?%@GB0CE FGHJ,KLMNOPQRSTUVWXYZ[\]^_`acdefghijkl5nopqstuwxyz{|~*'  ":5RBBĀ%wǀɀ |̀N-πӀT&ր.ـڀۀ܀{djQTy-;.)A    (DOx_P=t!#%.&'()+ ,G./0123E5 6789:;<=>@ABCDEFGHIJKLMNO3QR TUVWXYZ[\]^_`abc;dfzgpi0jLlmnopqrstuvwxyz{|}~ր׀؀ـڀۀ܀݀ހ߀Xh^% B"(Y ' , ! #$%Q'(%*,,-0//0 235689:;<0>?@_BCDEFGIJKLMN2OPQR-TUVW7XYZ \]^_`abcd-fghijklmno pqrstuvwxy{|}~  DGM7>  &&,. :A-112-89aRenal:T-77100 M-72030Gross A-112-89-01.Diagnosis: Nodular hyperplasia of the prostateThe prostatic urethra and the urinary bladder have been opened, anteriorly in the midline, showing the nodularity of the hypertrophic prostate.DGyM2<  $$*, 8A-131-62RenalT-71000 D-6502Gross A-131-62-010X]Diagnosis: Acute bilateral pyelonephritis, necrotizing papillitis, and chronic pyelonephritis]Both kidneys with portions of their ureters. The patient had acute bilateral pyelonephritis.DGfSM1<  $$*, 8A-131-62lRenalT-71000 D-6502Gross A-131-62-02!]Diagnosis: Acute bilateral pyelonephritis, necrotizing papillitis, and chronic pyelonephritis\Close-up view of the external surface of one of the kidneys demonstrating several abscesses.DGEM<  $$*, 8A-16-70Renal/T-X2000 M-8312/3Gross A-16-70-01"f5Diagnosis: Renal cell carcinoma with brain metastaseshConvexities of the brain with a hemorrhagic metastatic tumor bulging out from its right parietal region.DG'@M<  $$*, 8A-16-70Renal0T-X2000 M-8312/3Gross A-16-70-02A":5Diagnosis: Renal cell carcinoma with brain metastasesmThe sagital section of the same brain better demonstrating the hemorrhagic mass in the right parietal region.DGpM2D  &&24 @A-205-75iRenalT-71000 M-68130c H & E Stain A-205-75-019?Diagnosis: Proliferative glomerulonephritis (non-streptococcal)sLight microscopy of a glomerulus in this patient showing marked increase in the cellularity of the glomerular tuft.DGMJ  &&8: FA-205-75iRenalT-71000 M-46812cImmunfluorescence A-205-75-029?Diagnosis: Proliferative glomerulonephritis (non-streptococcal)A glomerulus showing a positive reaction with anti-IgG conjugate staining both the mesangium and the capillary loops in a non-linear ("lumpy-bumpy") pattern. (Utilizing the Direct Immunofluorescence Technique)DG6M D:  ""(* 6A-74-59RenalT-71010 D-7382Gross A-74-59-01!Diagnosis: Malignant hypertensionThe external surface of the kidney, after the renal capsule has been stripped off, showing a "flea-bitten" appearance of the kidney in a patient with malignant hypertension.DGM G<  $$*, 8A-78-62Renal9T-74000 M-8120/3Gross A-78-62-01;5r_Diagnosis: Poorly differentiated transitional cell carcinoma of the urinary bladder (Grade III)pAn opened urinary bladder to expose its mucosal surface, showing a large ulcerated fungating tumor at it's dome.DGK)M %<  $$*, 8A-86-64Renal)T-32020 M-8312/3Gross A-86-64-01%P:Diagnosis: Renal cell carcinoma with widespread metastasessThe heart with it's pericardial sack cut open to expose several gray-white tumor nodules on it's extrernal surface.DG5M <  $$*, 8A-86-64Renal*T-32020 M-8312/3Gross A-86-64-028:Diagnosis: Renal cell carcinoma with widespread metastasesaSame heart with it's left ventricular chamber having been cut open to show several tumor nodules.DG*M <  $$*, 8A-86-64Renal+T-32020 M-8312/3Gross A-86-64-030z:Diagnosis: Renal cell carcinoma with widespread metastases Close-up viewDG&M6<  $$*, 8A-91-63Renal&T-71020 M-8312/3Gross A-91-63-01!:Diagnosis: Renal cell carcinoma with widespread metastasesThe kidney with it's ureter attached to it. The renal capsule has been stripped off and a large tumor is present in its lower pole.DGkM^<  $$*, 8A-91-63Renal'T-71020 M-8312/3Gross A-91-63-023*:Diagnosis: Renal cell carcinoma with widespread metastasesThe same kidney cut into two sections. The cut surface of the large tumor has a variagated appearance with gray-white regions of fibrosis in a golden yellow tumor tissue. DGM<  $$*, 8A-91-63Renal(T-56000 M-8312/3Gross A-91-63-03+8:Diagnosis: Renal cell carcinoma with widespread metastasesgThe cut surface of the liver showing a subcapsular metastasis with a central depression "umbilication".DGfM<  $$*, 8A-94-58Renal$T-71010 M-8140/0Gross A-94-58-01#1/Diagnosis: Cortical adenoma of the right kidneyoA slice of the kidney showing a small, round well-demarcated subcapsular gray-white tumor nodule in its cortex.DGXMB  $$02 >A-94-58Renal%T-71010 M-8140/0 H & E Stain A-94-58-0249/Diagnosis: Cortical adenoma of the right kidneyVPhotomicrograph of the renal cortical adenoma showing branching pappillomatous patternDGĶM<  $$*, 8A-97-63RenalT-71800 M-26730uGross A-97-63-01!D+Diagnosis: Adult polycystic kidney disease Two kidneys attached to a segment of abdominal aorta via their renal arteries and to the urinary bladder via their ureters. Kidneys are massively enlarged and distorted in shape due to presence of multiple unilocular cysts.DG9M.<  $$*, 8A-97-63RenalT-71800 M-00100Gross A-97-63-02!$B+Diagnosis: Adult polycystic kidney disease The external surface of one of the two kidneys is compared to a normal kidney, which has been placed to the right of the polycystic kidney.DGbM<  $$*, 8A-97-63RenalT-72000 M-8120/3Gross A-97-63-038+Diagnosis: Adult polycystic kidney disease NOverall view of the cut surfaces of the two polycystic kidneys after fixation.DGh`M<  $$*, 8A-97-63RenalT-71800 M-26730Gross A-97-63-049+Diagnosis: Adult polycystic kidney disease FClose-up view of the cut surface of one of the two polycystic kidneys.DG(!M"<  $$*, 8A-97-63RenalT-56000 M-26730Gross A-97-63-05D8:+Diagnosis: Adult polycystic kidney disease Cut surface of the liver showing a solitary cyst in the parenchyma of the liver of this patient with polycystic kidney disease.DGXM>  &&,. :CC-56-63 RenalT-71000 M-20100 Gross CC-56-63-01 ~Diagnosis: Severe dilatation of the bladder, hydroureters, and hydronephrosis secondary to severe obstructive nodular hyperplasia of the prostate with horseshoe kidney Two kidneys attached at the medial aspect of their lower poles with ureters originating from lateral aspects of their lower poles. The ureters are dilated and attached at their distal ends to a distended urinary bladder.DGB0M>  &&,. :CC-56-63 RenalT-71000 M-20100 Gross CC-56-63-02 Diagnosis: Severe dilatation of the bladder, hydroureters, and hydronephrosis secondary to severe obstructive nodular hyperplasia of the prostate with horseshoe kidney The bladder has now been opened along it's vertical axis to show the obstruction of the prostatic urethra caused by nodular hyperplasia of the prostate. Trabeculation of the urinary bladder is also seen.DGM`>  &&,. :CC-56-63 RenalT-77100 M-72030 Gross CC-56-63-03 Diagnosis: Severe dilatation of the bladder, hydroureters, and hydronephrosis secondary to severe obstructive nodular hyperplasia of the prostate with horseshoe kidney >Close-up view of the propstatic urethra and enlarged prostate.DGl+M<  $$*, 8CC-56-63 RenalT-74000 D-6810Gross CC-56-63-049Diagnosis: Severe dilatation of the bladder, hydroureters, and hydronephrosis secondary to severe obstructive nodular hyperplasia of the prostate with horseshoe kidney gClose-up of the urinary bladder showing the marked trabeculation of the mucosal surface of the bladder.DGFHM>  &&,. :CC-56-63 RenalT-71000 M-20100 Gross CC-56-63-05 Diagnosis: Severe dilatation of the bladder, hydroureters, and hydronephrosis secondary to severe obstructive nodular hyperplasia of the prostate with horseshoe kidney gSurfaces made by cutting to demonstrate the hydronephrosis of the horseshoe kidney and the hydrouretersDGMX>  &&,. :CC-56-63 Renal T-71000 M-33300 Gross CC-56-63-068FDiagnosis: Severe dilatation of the bladder, hydroureters, and hydronephrosis secondary to severe obstructive nodular hyperplasia of the prostate with horseshoe kidney 6Close-up view of the opened kidney with hydronephrosisDG4oM8H ((46 D S-10023-90iRenal T-71000 M-68130l H & E Stain S-10023-90-01/(Diagnosis: Membranous glomerulonephritisPhotomicrograph of the glomerulus showing marked thickening of the glomerular capillary loop walls and no glomerular hypercellularity.DGUM%N ((:< J S-10023-90iRenal T-71000 M-68130lImmunfluorescence S-10023-90-028(Diagnosis: Membranous glomerulonephritissDirect immunofluorescence photomicrograph of the glomerulus showing non-linear staining of the capillary walls. DG9M 9P ((<> L S-10023-90iRenalT-71000 M-68130lElectron Micrograph S-10023-90-03(Diagnosis: Membranous glomerulonephritisElectron micrograph of the glomerulus showing many subepithelial electron dense deposits with marked fusion of foot processes. DGHM!@  &&,. < S-1108-87Renal<T-77100 M-8140/3Gross S-1108-87-01d!*Diagnosis: Adenocarcinoma of the prostate5Gross photograph of a radical prostatectomy specimen DGrM"@  &&,. < S-1108-87Renal=T-77100 M-8140/3Gross S-1108-87-026h*Diagnosis: Adenocarcinoma of the prostateuGross photograph of cut surfaces of the prostate showing a homogenous region suggestive of infiltrating carcinoma DG[M#F  &&24 B S-1108-87Renal>T-77100 M-8140/3 H & E Stain S-1108-87-03h9*Diagnosis: Adenocarcinoma of the prostate7Photomicrograph of the adenocarcinoma of the prostate. DGtM$SD  $$02 @ S-1116-90RenalT-71000 D-3890 H & E Stain S-1116-90-01=6Diagnosis: AmyloidosisLight microscopic picture of H&E stained microscopic section of the glomerulus with amyloid deposition in the affarent arteriole showing a nuclear, homogenous, eosinophilic appearanceDGM%D  $$02 @ S-1116-90RenalT-56000 D-3890 H & E Stain S-1116-90-02$9<Diagnosis: AmyloidosisJPhotomicrograph of the liver with amyloid deposited around hepatocytes.DG3M&H &&46 D S-14511-90rRenal T-71000 D-6755 Special Stain S-14511-90-019,Diagnosis: Minimal change glomerulonephritisXPAS stained photomicrograph of the glomerulus which appears normal by light microscopy. DG'M'!N &&:< J S-14511-90Renal T-71000 D-6755Electron Micrograph S-14511-90-023,Diagnosis: Minimal change glomerulonephritiskElectron micrography of the glomerulus showing fusion of foot processes and no electron dense deposits. DG<)M( @  &&,. < S-1928-67Renal7T-71020 D-8120/3Gross S-1928-67-01CdeDiagnosis: Superficially invasive, well-differentiated transitional cell carcinoma of the left ureter+External surface of kidney with hydroureterDG|M) @  &&,. < S-1928-67Renal8T-71020 D-8120/3Gross S-1928-67-02 eDiagnosis: Superficially invasive, well-differentiated transitional cell carcinoma of the left ureter(Cut surface of kidney with opened ureterDG|M*@  &&,. < S-3028-86Renal1T-72000 M-8120/3Gross S-3028-86-01b B:Diagnosis: Transitional cell carcinoma of the renal pelvis/Transitional cell carcinoma of the renal pelvisDGM+8  $& 4 S-3028-86Renal2M-8120/3Gross S-3028-86-021:Diagnosis: Transitional cell carcinoma of the renal pelvisXCross section of tumor (transitional cell carcinoma of the renal pelvis) after fixation.DGM,i@  &&,. < S-3809-71Renal!T-71010 M-33300nGross S-3809-71-01"f?Diagnosis: Calculous disease, hydronephrosis and pyelonephritisExternal surface of the kidney with its capsule stripped off, showing a markedly dilated pelvis and puckered regions of scarring on the external surface of the kidney. DG.M-@  &&,. < S-3809-71Renal"T-71010 M-30001nGross S-3809-71-02!?Diagnosis: Calculous disease, hydronephrosis and pyelonephritis`The kidney has now been opened along its pelvis & calyces to show a large staghorn caculus.DG \M. 6  "$ 2 S-3809-71Renal#M-30001Gross S-3809-71-03"?Diagnosis: Calculous disease, hydronephrosis and pyelonephritisYCaculus has now been removed to show the large staghorn caculus & some of its fragments. DGHM/@  &&,. < S-3827-63Renal?T-78020 M-9061/3Gross S-3827-63-01 (&Diagnosis: Seminoma of the left testis+External surface of seminoma of the testis.DGyTM0@  &&,. < S-3827-63Renal@T-78020 M-9061/3Gross S-3827-63-02&Diagnosis: Seminoma of the left testis&Cut surface of seminoma of the testis.DG M1N@  &&,. < S-4050-58Renal,T-71000 M-8312/3Gross S-4050-58-01 EDiagnosis: Renal cell carcinoma with renal vein invasion, left kidneyPhotograph of the cut surface of the kidney and opened renal vein showing renal cell carcinoma (in the kidney) invading the renal vein.DG@M28  $& 4 S-4314-79Renal4M-8960/3 Gross S-4314-79-01K$,Diagnosis: Unusual variant of a Wilms tumorWilms tumor - External surfaceDGSM38  $& 4 S-4314-79Renal5M-8960/3eGross S-4314-79-0221,Diagnosis: Unusual variant of a Wilms tumorWilms tumor - Cut surfaceDGBM4>  *, : S-4314-79Renal6M-8960/3 H & E Stain S-4314-79-03:3,Diagnosis: Unusual variant of a Wilms tumor6Photomicrograph showing small blue round cell tumor.DG.M58  (* 4S-5-72 Renal-M-8312/3s H & E Stain S-5-72-019CDiagnosis: Renal cell carcinoma with metastatic involvement of bone2Low power photomicrograph of renal cell carcinoma DGHMM68  (* 4S-5-72 Renal.M-8312/3s H & E Stain S-5-72-029bCDiagnosis: Renal cell carcinoma with metastatic involvement of bone3High power photomicrograph of renal cell carcinoma DG M7@  &&,. < S-6342-72RenalT-71020 M-33404nGross S-6342-72-01#f1Diagnosis: Large solitary cyst of the left kidneyhPhotograph of the external surface of the kidney showing a large thin walled cyst in the upper pole. DGDM8@  &&,. < S-6342-72Renal T-71020 M-33404lGross S-6342-72-02<$1Diagnosis: Large solitary cyst of the left kidney?Cut surface of the kidney showing that the cyst is unilocular. DGM9D  $$02 @ S-6369-75RenalT-71000 D-6740 H & E Stain S-6369-75-019n!Diagnosis: Goodpastures syndrome6Photomicrograph of the glomerulus showing a crescent. DGM:J  $$68 F S-6369-75RenalT-71000 D-6740Immunfluorescence S-6369-75-02F4!Diagnosis: Goodpastures syndromesDirect immunofluorescence photomicrograph of the glomerulus showing linear staining of the capillary loop walls.DGM;L  $$8: H S-6369-75RenalT-71000 D-6740Electron Micrograph S-6369-75-03 `!Diagnosis: Goodpastures syndromeTElectron micrograph of the glomerulus showing absence of electron dense deposits.DGM<F  &&24 B S-7787-72RenalT-71800 M-26730 H & E Stain S-7787-72-01&H*Diagnosis: Adult polycystic kidney disease1Section mount of adult polycystic kidney disease DGM=F  &&24 B S-7787-72RenalT-71800 M-26730 H & E Stain S-7787-72-02q9*Diagnosis: Adult polycystic kidney disease3Photomicrograph of adult polycystic kidney disease DG 8M>F  $$24 B S-8205-75RenalT-71000 D-6740 Special Stain S-8205-75-019Gross A-92-61-03I9v2Diagnosis: Chronic passive congestion of the liverPCloseup view of surfaces made by cutting of liver with acute passive congestion.DGwMT6  $& 2A-92-61Cardiovascular^Gross A-92-61-0492Diagnosis: Chronic passive congestion of the liverIClose-up view of cut surface - "nutmeg liver" (acute passive congestion) DG YMU@   ,. < S-4763-73Cardiovascular H & E Stain S-4763-73-019+Diagnosis: Giant cell or temporal arteritisTemporal arteritisDGMV@   ,. < S-4763-73Cardiovascular H & E Stain S-4763-73-02]9+Diagnosis: Giant cell or temporal arteritistemporal arteritisDGMW>   ,. :CC-49-64Cardiovascularr H & E Stain CC-49-64-019   ,. :A-158-67Cardiovascular H & E Stain A-158-67-019BODiagnosis: Severe severely obstructing atherosclerosis of the coronary arteries=The photograph is a cross sectional view of a coronary arteryDG MY6  $& 2A-68-58CardiovascularGross A-68-58-012_Diagnosis: Severe hypertensive heart disease and severe arteriolonephrosclerosis - cardiomegaly3Hypertensive heart (L) compared to normal heart (R)DG|MZ<  *, 8A-68-58CardiovascularD H & E Stain A-68-58-029_Diagnosis: Severe hypertensive heart disease and severe arteriolonephrosclerosis - cardiomegaly-Kidney with hyperplastic arteriololosclerosisDGY/M[<  *, 8A-68-58Cardiovascular H & E Stain A-68-58-03U9_Diagnosis: Severe hypertensive heart disease and severe arteriolonephrosclerosis - cardiomegaly0Fibernoid necrosis of an arteriole in the kidneyDGnhM\8   &( 4A-179-64Cardiovascular Gross A-179-64-019 ?Diagnosis: Mitral stenosis - chronic rheumatic valvular disease_Photograph of opened left atrium with characteristic "fish mouth" deformity of the mitral valveDGM]>8   &( 4A-179-64Cardiovascular!Gross A-179-64-028?Diagnosis: Mitral stenosis - chronic rheumatic valvular diseasePhotograph of opened left side of the heart with enlarged left atrium and small left ventricle separated by fused and scarred mitral valve.DGrM^V8   &( 4A-210-71CardiovascularGross A-210-71-015,-Diagnosis: Chronic rheumatic valvular diseasePhotograph of opened left side of the heart with enlarged left atrium and small left ventricle separated by scarred and fused mitral valve with shortened and fused chordae tendineaeDGmM_8   &( 4A-210-71CardiovascularGross A-210-71-026-Diagnosis: Chronic rheumatic valvular disease+Closeup photograph of deformed mitral valveDGFbM`8   &( 4CC-56-71Cardiovascular"Gross CC-56-71-01,*#Diagnosis: Calcific aortic stenosisRSuperior view of heart with chronic calcific nodular sclerosis of the aortic valveDG5Ma8   &( 4CC-56-71Cardiovascular#Gross CC-56-71-029#Diagnosis: Calcific aortic stenosis,Concentric hypertrophy of the left ventricleDG+Mb6  $& 2A-13-87Cardiovascular$Gross A-13-87-01"Diagnosis: Severe ischemic heart disease. Significant stenosing coronary atherosclerosis with saphenous vein and internal mammary artery bypass grafts and mural thrombosis of the left ventricle with systemic embolizationZExternal appearance of the heart with bread and butter pericarditis" (acute pericarditis)DG3Mck<  *, 8A-13-87Cardiovascular% H & E Stain A-13-87-029Diagnosis: Severe ischemic heart disease. Significant stenosing coronary atherosclerosis with saphenous vein and internal mammary artery bypass grafts and mural thrombosis of the left ventricle with systemic embolizationFibrinous percarditisDGMdp6  $& 2A-13-87Cardiovascular&Gross A-13-87-039pDiagnosis: Severe ischemic heart disease. Significant stenosing coronary atherosclerosis with saphenous vein and internal mammary artery bypass grafts and mural thrombosis of the left ventricle with systemic embolization Opened heart with mural thrombusDG{4Me6  $& 2A-13-87Cardiovascular'Gross A-13-87-046Diagnosis: Severe ischemic heart disease. Significant stenosing coronary atherosclerosis with saphenous vein and internal mammary artery bypass grafts and mural thrombosis of the left ventricle with systemic embolization2Overall view of spleen with recent embolic infarctDG>Mf6  $& 2A-13-87Cardiovascular(Gross A-13-87-05U7Diagnosis: Severe ischemic heart disease. Significant stenosing coronary atherosclerosis with saphenous vein and internal mammary artery bypass grafts and mural thrombosis of the left ventricle with systemic embolization3Close-up view of spleen with recent embolic infarctDGYMg?6  $& 2A-72-88Cardiovascular)Gross A-72-88-01"Diagnosis: Acute coronary thrombosis. Acute myocardial infarction with rupture of the free wall of the left ventricle and hemopericardiumCPhotograph of opened pericardial sac with contained hemopericardiumDGMh=6  $& 2A-72-88Cardiovascular*Gross A-72-88-02VDiagnosis: Acute coronary thrombosis. Acute myocardial infarction with rupture of the free wall of the left ventricle and hemopericardiumAPhotograph of a coronary artery with a contained acute thrombosisDG=Mi 6  $& 2A-72-88Cardiovascular+Gross A-72-88-03 &Diagnosis: Acute coronary thrombosis. Acute myocardial infarction with rupture of the free wall of the left ventricle and hemopericardium$Rupture of the left ventricular wallDG)Mj,<  *, 8A-72-88Cardiovascular, H & E Stain A-72-88-049Diagnosis: Acute coronary thrombosis. Acute myocardial infarction with rupture of the free wall of the left ventricle and hemopericardium*Acute myocardial infarct (12-24 hours old)DG Mk:   &( 6 CC-124-90Cardiovascular-rGross CC-124-90-015:KDiagnosis: Chronic ischemic heart disease with an old myocardial infarction6Old myocardial infarct - overall view of cross sectionDGKMl:   &( 6 CC-124-90Cardiovascular.dGross CC-124-90-02.KDiagnosis: Chronic ischemic heart disease with an old myocardial infarction!Old myocardial infarct - close-upDGKMm@   ,. < CC-124-90Cardiovascular$/ H & E Stain CC-124-90-03X9KDiagnosis: Chronic ischemic heart disease with an old myocardial infarction3Mature scar tissue and hypertrophic cardiac muscle.DGJlMn8   &( 4CC-82-69Cardiovascular<0hGross CC-82-69-0199Diagnosis: Huge syphilitic aneurysm of the thoracic aorta Hemothorax DG(Mo8   &( 4CC-82-69Cardiovascular1Gross CC-82-69-02"9Diagnosis: Huge syphilitic aneurysm of the thoracic aorta,Large syphilitic aneurysm of the aortic archDG_Mp<  *, 8CC-7-57Cardiovascular 2 H & E Stain CC-7-57-016TTDiagnosis: Severe generalized fibrinous and fibrous pericarditis due to tuberculosis2Langhans' giant cells in granulomatis pericarditisDGMq8   &( 4A-104-90Cardiovascular3Gross A-104-90-03"GDiagnosis: Restrictive cardiomyopathy secondary to systemic amyloidosisEnlarged heartDGMr8   &( 4A-104-90?Cardiovascular?42Gross A-104-90-04#GDiagnosis: Restrictive cardiomyopathy secondary to systemic amyloidosis3Cross section of heart with subtle diffuse palenessDGJMs8   &( 4A-104-90Cardiovascular5;Gross A-104-90-055GDiagnosis: Restrictive cardiomyopathy secondary to systemic amyloidosis,Closeup of surfaces made by cutting of heartDGkMt>   ,. :A-104-90FCardiovascular>6U H & E Stain A-104-90-069GDiagnosis: Restrictive cardiomyopathy secondary to systemic amyloidosis+Amyloid deposition around myocardial fibersDG:2Mu@   .0 <A-104-90!Cardiovascular/7 Special Stain A-104-90-079GDiagnosis: Restrictive cardiomyopathy secondary to systemic amyloidosis$Phor-White stain of amyloid in heartDGMv8   &( 4A-104-90Cardiovascular8Gross A-104-90-084^GDiagnosis: Restrictive cardiomyopathy secondary to systemic amyloidosisLiver with subtle palenessDG/Mw8   &( 4 A-104-90JCardiovascularY9zGross A-104-90-09 GDiagnosis: Restrictive cardiomyopathy secondary to systemic amyloidosis%Section of liver with subtle palenessDG`Mx8   &( 4 A-104-90Cardiovascular:wGross A-104-90-109GDiagnosis: Restrictive cardiomyopathy secondary to systemic amyloidosis5Closeup photograph of liver with altered architectureDGHMy>   ,. : A-104-908Cardiovascular; H & E Stain A-104-90-115GDiagnosis: Restrictive cardiomyopathy secondary to systemic amyloidosisAmyloid deposition in liverDG(Mz@   .0 < A-104-90Cardiovascular<* Special Stain A-104-90-129GDiagnosis: Restrictive cardiomyopathy secondary to systemic amyloidosis$Phor-White stain of amyloid in liverDGS?M{8   &( 4 A-104-90Cardiovascular=+Gross A-104-90-138XGDiagnosis: Restrictive cardiomyopathy secondary to systemic amyloidosisPhotograph of enlarged spleenDGM|8   &( 4A-104-90rCardiovascularn>Gross A-104-90-147|GDiagnosis: Restrictive cardiomyopathy secondary to systemic amyloidosisJPhotograph of surfaces made by cutting of spleen with altered architectureDGZ1M}>   ,. :A-104-90CardiovascularJ? H & E Stain A-104-90-1596GDiagnosis: Restrictive cardiomyopathy secondary to systemic amyloidosisAmyloid deposition in spleenDGIM~@   .0 <A-104-90Cardiovascular@ Special Stain A-104-90-169|GDiagnosis: Restrictive cardiomyopathy secondary to systemic amyloidosis%Phor-White stain of amyloid in spleenDGM7M8   &( 4A-104-906Cardiovascular3ACGross A-104-90-178*GDiagnosis: Restrictive cardiomyopathy secondary to systemic amyloidosisPhotographs of kidneysDGFgM>   ,. :A-104-900CardiovascularB H & E Stain A-104-90-187XGDiagnosis: Restrictive cardiomyopathy secondary to systemic amyloidosisAmyloid deposition in kidneyDGM4   "$ 0A-104-90bCardiovascularCQ A-104-90-19^GDiagnosis: Restrictive cardiomyopathy secondary to systemic amyloidosis6Protein electrophoresis with monoclonal peak, (arrow).DGF9M4   "$ 0A-104-90lCardiovasculareDrr A-104-90-209|GDiagnosis: Restrictive cardiomyopathy secondary to systemic amyloidosisMImmunofixation electrophoresis with evidence of IgA lambda monoclonal proteinDGM4   "$ 0A-104-90 CardiovascularcEal A-104-90-21GDiagnosis: Restrictive cardiomyopathy secondary to systemic amyloidosisWUrinary protein electrophoresis with monoclonal protein (Bence-Jones protein), (arrow).DG+ M6  $& 2A-78-65CardiovascularFcGross A-78-65-01y!D1Diagnosis: Non-bacterial thrombotic endocarditis]Opened left side of the heart with a nonbacterial thrombotic endocarditis of the mitral valveDGbuM6  $& 2A-78-65CardiovascularGtGross A-78-65-02 41Diagnosis: Non-bacterial thrombotic endocarditisECloseup of the mitral valve with nonbacterial thrombotic endocarditisDGbM 6  $& 2A-91-70CardiovascularH Gross A-91-70-018bDiagnosis: Cardiac changes due to widespread metastatic carcinoid tumor primary in the small bowel6Carcinoid changes of the pulmonic valve - overall viewDGYM 6  $& 2A-91-70CardiovascularI Gross A-91-70-02~8bDiagnosis: Cardiac changes due to widespread metastatic carcinoid tumor primary in the small bowel7Carcinoid changes of the pulmonic valve - close-up viewDGM>6  $& 2CC-4-80CardiovascularJdGross CC-4-80-01Diagnosis: An acute infectious endocarditis of the mitral valve superimposed on a chronic rheumatic heart disease. (Libman-Sacks disease)BOpen left side of the heart with large vegetations on mitral valveDG=M6  $& 2CC-4-80CardiovascularKeGross CC-4-80-02=9*Diagnosis: An acute infectious endocarditis of the mitral valve superimposed on a chronic rheumatic heart disease. (Libman-Sacks disease)Closeup of large vegetationDG_M96  $& 2CC-4-80CardiovascularLoGross CC-4-80-03x9Diagnosis: An acute infectious endocarditis of the mitral valve superimposed on a chronic rheumatic heart disease. (Libman-Sacks disease)=Bacterial endocarditis and chronic rheumatic valvular diseaseDG*M"<  *, 8CC-4-80CardiovascularMd H & E Stain CC-4-80-0472Diagnosis: An acute infectious endocarditis of the mitral valve superimposed on a chronic rheumatic heart disease. (Libman-Sacks disease) Bacterial colonies in vegetationDGQiM4  "$ 0A-113-86l RespiratoryoGross A-113-86-01"l/Diagnosis: Adult respiratory distress syndrome[Surfaces made by cutting of right lung with changes of adult respiratory distress syndrome.DG M4  "$ 0A-113-86a Respiratory Gross A-113-86-02!j/Diagnosis: Adult respiratory distress syndrome^Surfaces made by cutting of the left lung with changes of adult respiratory distress syndrome.DG|M4  "$ 0A-113-86 RespiratoryGross A-113-86-03"*/Diagnosis: Adult respiratory distress syndromeCloseup of previous picture.DG9M:  (* 6A-113-86 Respiratory H & E Stain A-113-86-049/Diagnosis: Adult respiratory distress syndrome:Microscopic appearance of alveoli with granulation tissue.DG!M:  (* 6A-113-86 Respiratory H & E Stain A-113-86-059/Diagnosis: Adult respiratory distress syndromeiMicroscopic appearance of alveoli with contained macrophages, pneumocytes, protein and granulaton tissue.DGlM:  (* 6A-113-86z Respiratoryz H & E Stain A-113-86-069/Diagnosis: Adult respiratory distress syndromeyMicroscopic appearance similar to previous photomicrographs with the addition of a collection of polymorphonuclear cells.DG~M:  (* 6A-113-86 Respiratory H & E Stain A-113-86-079/Diagnosis: Adult respiratory distress syndrome&Higher power view of previous picture.DG]M2   " .A-59-88 RespiratoryGross A-59-88-01K#,$Diagnosis: Massive pulmonary embolus!Photograph of resected left lung.DG(M2   " .A-59-88 Respiratory Gross A-59-88-02'"$Diagnosis: Massive pulmonary embolusJCloseup photograph of left pulmonary artery with contained thromboembolus.DGIJM2   " .A-59-88 Respiratory Gross A-59-88-03,$Diagnosis: Massive pulmonary embolus%Photograph of removed thromboembolus.DGOrM8  &( 4A-59-88 Respiratory T H & E Stain A-59-88-04 9z$Diagnosis: Massive pulmonary embolus5Photomicrograph of thromboembolus with lines of Zahn.DGM4  "$ 0A-202-65 Respiratory "Gross A-202-65-01"%Diagnosis: Severe pulmonary emphysema6Surfaces made by cutting of right lung after fixation.DGOM4  "$ 0A-202-65 Respiratory Gross A-202-65-029%Diagnosis: Severe pulmonary emphysema5Close-up photograph of blebs in the right upper lobe.DG*M:  (* 6A-202-65 Respiratory H & E Stain A-202-65-039%Diagnosis: Severe pulmonary emphysema&Microphotograph of emphysematous lung.DGM6  $& 2A-202-65 RespiratoryAutopsy A-202-65-04%%Diagnosis: Severe pulmonary emphysemaNPhotograph of right hand with clubbing of fingers (pulmonary osteoarthropathy)DGMM4  "$ 0CC-66-89 RespiratoryGross CC-66-89-01"Diagnosis: Lobar pneumoniaPhotograph of pleural fluid.DG)M4  "$ 0CC-66-89 RespiratoryGross CC-66-89-02#Diagnosis: Lobar pneumonia Left lung.DG2M4  "$ 0CC-66-89 RespiratoryGross CC-66-89-03#vDiagnosis: Lobar pneumonia5Gross photograph of surfaces made by cutting of lung.DGX^M4  "$ 0CC-66-89 RespiratoryGross CC-66-89-04# Diagnosis: Lobar pneumoniaCloseup of previous photograph.DGdM:  (* 6CC-66-89 Respiratory H & E Stain CC-66-89-059Diagnosis: Lobar pneumoniaPPhotomicrograph with confluent intraalveolar exudation (polymorphonuclear cells)DG~M:  (* 6CC-66-89 Respiratory H & E Stain CC-66-89-069Diagnosis: Lobar pneumonia1Higher power photomicrograph of previous picture.DGM4  "$ 0A-188-69 RespiratoryGross A-188-69-01"'Diagnosis: Pulmonary atypical pneumoniaOverall view of the left lung.DG1M4  "$ 0A-188-69 RespiratoryGross A-188-69-02%'Diagnosis: Pulmonary atypical pneumonia*Surfaces made by cutting of the left lung.DG.M4  "$ 0A-188-69 RespiratoryGross A-188-69-038'Diagnosis: Pulmonary atypical pneumoniaCloseup of previous picture.DGM:  (* 6A-188-69 Respiratory H & E Stain A-188-69-049'Diagnosis: Pulmonary atypical pneumonia>Microscopic appearance of lung with interstitial infiltration.DGAM:  (* 6A-188-69 Respiratory H & E Stain A-188-69-058'Diagnosis: Pulmonary atypical pneumonia.Higher power view of previous photomicrograph.DGEM:  (* 6A-188-69 Respiratory H & E Stain A-188-69-068'Diagnosis: Pulmonary atypical pneumoniaDCloseup of previous photomicrograph with chronic inflammatory cells.DGM6  "$ 2 S-1116-75 RespiratoryGross S-1116-75-01!#Diagnosis: Abscess of the left lungLeft lung with abscess.DG-M 4  "$ 0CC-30-60 RespiratoryGross CC-30-60-012HDiagnosis: Active pulmonary tuberculosis with fatal pulmonary hemorrhageTSurfaces made by cutting of resected lung with multiple areas of caseation necrosis.DG=M4  "$ 0CC-30-60 Respiratory Gross CC-30-60-027HDiagnosis: Active pulmonary tuberculosis with fatal pulmonary hemorrhageCloseup of previous picture.DGM:  (* 6CC-30-60 Respiratory! H & E Stain CC-30-60-039HDiagnosis: Active pulmonary tuberculosis with fatal pulmonary hemorrhage7Photomicrograph of characteristic Langhans' giant cell.DG11M6  "$ 2 S-3271-90 Respiratory"X-Ray S-3271-90-019Diagnosis: Pulmonary hamartoma$Chest x-ray with mass in right lung.DG@M6  "$ 2 S-3271-90 Respiratory#X-Ray S-3271-90-02%Diagnosis: Pulmonary hamartoma7Lateral chest film with evidence of mass in lower lobe.DGs M6  "$ 2 S-3271-90 Respiratory$X-Ray S-3271-90-03G/Diagnosis: Pulmonary hamartoma$CT of chest with mass in right lung.DGiM6  "$ 2 S-3271-90 Respiratory%Gross S-3271-90-04%Diagnosis: Pulmonary hamartoma Resected massDG1M6  "$ 2 S-3271-90 Respiratory&Gross S-3271-90-05L7,Diagnosis: Pulmonary hamartomaClose-up of the resected massDGDPM6  "$ 2 S-3271-90 Respiratory'/Gross S-3271-90-06i""Diagnosis: Pulmonary hamartoma.Surfaces made by cutting of the resected mass.DGyM<  (* 8 S-3271-90 Respiratory( H & E Stain S-3271-90-079Diagnosis: Pulmonary hamartoma7Photomicrograph of condroadenoma (pulmonary hamartoma).DGTNM'2   " .A-91-87 Respiratory)nX-Ray A-91-87-01-XDiagnosis: Bronchogenic squamous cell carcinoma of the lung with paraneoplastic syndromeaCT of a chest with evidence of a mass in the superior mediastinum, left lung, and overlying ribs.DGa@M2   " .A-91-87 Respiratory*bX-Ray A-91-87-02)PXDiagnosis: Bronchogenic squamous cell carcinoma of the lung with paraneoplastic syndromeBCT scan of chest with extension of mass into mediastinum and ribs.DG&M2   " .A-91-87 Respiratory+Gross A-91-87-03H"2XDiagnosis: Bronchogenic squamous cell carcinoma of the lung with paraneoplastic syndromeResected left lung.DG{4M2   " .A-91-87 Respiratory,Gross A-91-87-04!XDiagnosis: Bronchogenic squamous cell carcinoma of the lung with paraneoplastic syndrome*Close-up photograph of tumor in left lung.DGUIM8  &( 4A-91-87 Respiratory-p H & E Stain A-91-87-059XDiagnosis: Bronchogenic squamous cell carcinoma of the lung with paraneoplastic syndrome+Photomicrograph of squamous cell carcinoma.DGd`8  &( 4A-91-87 Respiratory. H & E Stain A-91-87-06o9~XDiagnosis: Bronchogenic squamous cell carcinoma of the lung with paraneoplastic syndromeDPhotomicrograph of tumor with evidence of karatin formation (pearl).DGOM@  .0 <A-91-87 Respiratory/Electron Micrograph A-91-87-079XDiagnosis: Bronchogenic squamous cell carcinoma of the lung with paraneoplastic syndromeDesmosomes and tonofilaments.DG3eM4  "$ 0S-744-73U Respiratory0Gross S-744-73-01"2JDiagnosis: Bronchogenic adenocarcinoma of the upper lobe of the right lung:Photograph of resected right lung with mass in upper lobe.DGYhM4  "$ 0S-744-73U Respiratory1UGross S-744-73-02$<JDiagnosis: Bronchogenic adenocarcinoma of the upper lobe of the right lungClose-up picture of mass.DGM4  "$ 0S-744-730 Respiratory2Gross S-744-73-03$ JDiagnosis: Bronchogenic adenocarcinoma of the upper lobe of the right lungLPhotograph of surfaces made by cutting in upper lobe of lung after fixation.DG1M:  (* 6S-744-73n Respiratory7e H & E Stain S-744-73-089JDiagnosis: Bronchogenic adenocarcinoma of the upper lobe of the right lung.Higher power view of abnormal cells in sputum.DG9M:  (* 6S-744-738 Respiratory5 H & E Stain S-744-73-069JDiagnosis: Bronchogenic adenocarcinoma of the upper lobe of the right lung-Higher power view of previous photomicrographDGgM:  (* 6S-744-73u Respiratory4t H & E Stain S-744-73-059JDiagnosis: Bronchogenic adenocarcinoma of the upper lobe of the right lung)Photomicrograph of tumor (adenocarcinoma)DG6FM:  (* 6S-744-73 Respiratory6z H & E Stain S-744-73-079NJDiagnosis: Bronchogenic adenocarcinoma of the upper lobe of the right lungDPhotomicrograph of sputum containing abnormal cells (adenocarcinoma)DG*M4  "$ 0S-744-73t Respiratory3nGross S-744-73-04!JDiagnosis: Bronchogenic adenocarcinoma of the upper lobe of the right lung'Close-up of tumor in upper lobe of lungDGM4  "$ 0A-109-88 Respiratory8X-Ray A-109-88-01(>(Diagnosis: Metastatic oat cell carcinomaCChest x-ray with irregular mass in the left upper lobe of the lung.DGVhM4  "$ 0A-109-88 Respiratory9X-Ray A-109-88-02."(Diagnosis: Metastatic oat cell carcinoma7CT scan of a lesion in the left upper lobe of the lung.DG?M4  "$ 0A-109-88# Respiratory:X-Ray A-109-88-03((Diagnosis: Metastatic oat cell carcinomaICT scan of a upper abdomen with numerous metastatic lesions in the liver.DGUM4  "$ 0A-109-88h Respiratory;aX-Ray A-109-88-04((Diagnosis: Metastatic oat cell carcinomaFBone scans with evidence of metastatic disease in the left second rib.DGUM4  "$ 0A-109-88 Respiratory<>X-Ray A-109-88-05((Diagnosis: Metastatic oat cell carcinomaFBone scans with evidence of metastatic disease in the left second rib.DGM\M4  "$ 0A-109-884 Respiratory=UGross A-109-88-06$*(Diagnosis: Metastatic oat cell carcinoma3Medial surface of the left lung with primary tumor.DGm"M4  "$ 0A-109-88 Respiratory>Gross A-109-88-07%(Diagnosis: Metastatic oat cell carcinomaCloseup of primary neoplasm. DG&M:  (* 6A-109-88 Respiratory? H & E Stain A-109-88-089(Diagnosis: Metastatic oat cell carcinomaBMicroscopic appearance of a small cell undifferentiated carcinoma.DGMB  02 > A-109-88 Respiratory@Electron Micrograph A-109-88-09%(Diagnosis: Metastatic oat cell carcinomaNeurosecretory granulesDGtM4  "$ 0 A-109-88 RespiratoryAGross A-109-88-108(Diagnosis: Metastatic oat cell carcinoma(Liver with extensive metastatic disease.DG$M4  "$ 0 A-109-88f RespiratoryBpGross A-109-88-117(Diagnosis: Metastatic oat cell carcinoma0Enlarged adrenal glands with metastatic disease.DGuM4  "$ 0 A-109-88a RespiratoryCpGross A-109-88-127(Diagnosis: Metastatic oat cell carcinomaASurfaces made by cutting of adrenal glands with focal hemorrhage.DGmM4  "$ 0 A-109-88 RespiratoryDGross A-109-88-130(Diagnosis: Metastatic oat cell carcinoma0Closeup of adrenal glands with focal hemorrhage.DGM:  (* 6A-109-88 RespiratoryE H & E Stain A-109-88-149(Diagnosis: Metastatic oat cell carcinomaLMicroscopic appearance of adrenal gland with contained "oat cell carcinoma".DGsM6  "$ 2 S-4044-61 RespiratoryFfGross S-4044-61-01?"KDiagnosis: Alveolar cell or terminal bronchiolar carcinoma of the left lung'Gross photograph of resected left lung.DGhM<  (* 8 S-4044-61 RespiratoryG H & E Stain S-4044-61-029KDiagnosis: Alveolar cell or terminal bronchiolar carcinoma of the left lung5Microscopic appearance of bronchioalveolar carcinoma DGpmM6  $& 2A-141-79S RespiratoryHAutopsy A-141-79-01!!Diagnosis: Malignant mesothelioma>Open chest cavity with markedly thickened pleura of left lung.DG&M6  $& 2A-141-79 RespiratoryIAutopsy A-141-79-028!Diagnosis: Malignant mesothelioma:Insitu picture of the left lung at autopsy (lateral view).DG2M4  "$ 0A-141-79W RespiratoryJGross A-141-79-03!!Diagnosis: Malignant mesothelioma4The dissected right lung with confluent mesotheliomaDGZM4  "$ 0A-141-79 RespiratoryKGross A-141-79-049J!Diagnosis: Malignant mesothelioma\Surfaces made by cutting of lung with involvement of all pleural surfaces with mesothelioma.DGM4  "$ 0A-141-79 RespiratoryLGross A-141-79-057!Diagnosis: Malignant mesothelioma)Closeup of section from previous picture.DG_M4  "$ 0A-141-79 RespiratoryMGross A-141-79-069!Diagnosis: Malignant mesotheliomaCloseup of previous picture.DGQM:  (* 6A-141-79 RespiratoryN H & E Stain A-141-79-079!Diagnosis: Malignant mesothelioma'Microscopic appearance of mesothelioma.DG(M:  (* 6A-141-79 RespiratoryO H & E Stain A-141-79-089!Diagnosis: Malignant mesothelioma&Higher power view of previous picture.DGDMB  02 > A-141-79 RespiratoryPElectron Micrograph A-141-79-099!Diagnosis: Malignant mesothelioma!Tumor with microvilli structures.DGz_M6  "$ 2 S-5411-72 RespiratoryQGross S-5411-72-015ADiagnosis: Squamous cell carcinoma of the left aryepiglottic foldResected larnyx with tumor.DG{vM<  (* 8 S-5411-72 RespiratoryR H & E Stain S-5411-72-029ADiagnosis: Squamous cell carcinoma of the left aryepiglottic foldcMicroscopic appearance of infiltrating poorly differentiated squamous cell carcinoma of the larnyx.DG_M6  "$ 2 S-5411-72 RespiratorySGross S-5411-72-03 ADiagnosis: Squamous cell carcinoma of the left aryepiglottic foldResected cervical lymph nodes.DGyM6  "$ 2 S-5411-72 RespiratoryTGross S-5411-72-04 hADiagnosis: Squamous cell carcinoma of the left aryepiglottic fold:Surfaces made by cutting of resected cervical lymph nodes.DG0M<  (* 8 S-5411-72 RespiratoryU H & E Stain S-5411-72-059ADiagnosis: Squamous cell carcinoma of the left aryepiglottic foldIMicroscopic appearance of metastatic keratinizing squamous cell carcinomaDGDM<  (* 8 S-5411-72 RespiratoryV H & E Stain S-5411-72-069ADiagnosis: Squamous cell carcinoma of the left aryepiglottic fold)Higher power view of previous photograph.DG ^H  $$&((46 D S-9520-96Central Nervous SystemGi H & E Stain S-9520-96-019TDiagnosis: Malignant glioma of the left frontal lobe, possibly an oligodendroglioma.ALow power of oligodendroglioma. Note the monotomy of the cells.DG(H  $$&((46 D S-9520-96Central Nervous SystemH H & E Stain S-9520-96-029TDiagnosis: Malignant glioma of the left frontal lobe, possibly an oligodendroglioma.$Oligodendroglioma with calcificationDG1CH  $$&((46 D S-9520-96Central Nervous SystemI H & E Stain S-9520-96-03|9TDiagnosis: Malignant glioma of the left frontal lobe, possibly an oligodendroglioma.%High power to show the nuclear detailDG2H  $$&((46 D S-9520-96Central Nervous SystemJ H & E Stain S-9520-96-04<5rTDiagnosis: Malignant glioma of the left frontal lobe, possibly an oligodendroglioma.CNS-7Central Nervous System Special StainCNS-7-01u99Diagnosis: Reactive astrocytes with GFAP immunoreactivityBReactive astrocytes with GFAP immunoreactivity - note how the processes surround the blood vessel as part of the blood brain barrier. Also notice the end feet of the astrocytes enclosing the blood vessels. They are components of the blood brain barrier. In a reactive process the processes are usually more elaborate.DGZM@   "$$02 <CNS-8Central Nervous System H & E StainCNS-8-019R6Diagnosis: Alzheimer's type ll protoplasmic astrocytesRAlzheimers type II protoplasmic astrocytes from a case of hepatic encephalopathy.DGNMB  ""$&&24 >CNS-10 Central Nervous System H & E Stain CNS-10-019Diagnosis: Corpora amylaceaCorpora amylacea / polyglucosan bodies / brain dust all are used to describe those amorphous basophilic structures found at the surface of the brain, around blood vessels and ventricles in older individuals. They are present within astrocytic cytoplasm. DGjpM@   "$$02 <CNS-9Central Nervous System H & E StainCNS-9-019Diagnosis: Rosenthal fibersWRosenthal fibers from a case of cerebellar astrocytoma. Rosenthal fibers are intracytoplasmic astrocytic accumulation of intermediate filaments. They are usually encountered in long standing lesions whether slow growing tumors, eg. Cerebellar astrocytomas, syringomyelic cavities whether secondary to tumors or traumatic injury of the cord. DG`MDB  ""$&&24 >CNS-11)Central Nervous System  H & E Stain CNS-11-0186Diagnosis: Granular ependymitisGranular ependymitis from a case of long standing hydrocephalus. Granular ependymitis was first described in cases of syhilis. This change has been noted in long standing hydrocephalus, where as a result of the stretching of the ependymal lining, there will be breaks in the lining resulting in proliferation of the subependymal layer of astrocytes to form pedunculated lesions that protrude into the ventricular cavity. DGMB  ""$&&24 >CNS-12)Central Nervous System H & E Stain CNS-12-019n$Diagnosis: Reactive microglial cellsRReactive microglial cells - gitter cells from a week old infarct. Gitter cells are modified / activated microglial cells or macrophages. They are an important part of tissue "clean up" following injury. There is usually an influx of blood monocytes in areas of injury as the intrinsic population might not able to handle the situation.DGM4<  ""$&&,. 8CNS-13Central Nervous System Gross CNS-13-018Diagnosis: HydrocephalusCoronal section of the brain with untreated hydrocephalus. Note that the brunt of the expansive process is reflected on the marked compressing of the white matter.DG#&MB  ""$&&24 >CNS-14Central Nervous System H & E Stain CNS-14-019Diagnosis: Aqueductal forking:Aqueductal forking from a case of congenital CMV infectionDGq0M4<  ""$&&,. 8CNS-15oCentral Nervous SystemGross CNS-15-014x.Diagnosis: Colloid cyst of the third ventricleCoronal section of the brain with a colloid cyst of the third ventricle that can act as a ball and valve producing intermittent hydrocephalus.DGM<  ""$&&,. 8CNS-16Central Nervous SystemGross CNS-16-013Diagnosis: Epidural hemorrhageEpidural hemorrhage from a case of untreated head trauma. Tear of the middle meningeal artery will produce an epidural hematoma.DG:Mi<  ""$&&,. 8CNS-17Central Nervous SystemGross CNS-17-01 &Diagnosis: Subdural hemorrhage chronicSubdural hemorrhage, chronic - note the compression of the brain. Tearing of the bridging veins is usually the cause of such bleeding. Most often seen in the elderly and alcoholics with frequent falls.DGEM<  ""$&&,. 8CNS-18Central Nervous SystemGross CNS-18-01 4FDiagnosis: Marked flattening of the gyri and obliteration of the sulciMarked flattening of the gyri and obliteration of the sulci. In a case of cerebral edema regardless of the cause, the gross appearance of the brain will reflect the increased volume of the brain and its compression and flattening against the skull.DG0MB  ""$&&24 >CNS-19Central Nervous System% H & E Stain CNS-19-019Diagnosis: Cerebral edemagH&E stained section of brain with cerebra edema. The accumulation of the edema fluid is extracellular.DGMn<  ""$&&,. 8CNS-20Central Nervous SystemGross CNS-20-0148*Diagnosis: Cerebellar tonsillar herniationSpace occupying lesions will increase the volume of the brain and as a result the brain will herniate downwards through the forman magnum producing those characteristic markings on the cerebellar tonsils.DGM@<  ""$&&,. 8CNS-21Central Nervous SystemGross CNS-21-013Diagnosis: Duret hemorrhageDuret hemorrhage is another sign of increased intracranial pressure, characteristically is present in the lower mid brain and upper pons, and results from vascualr stasis. DGM<  ""$&&,. 8CNS-22Central Nervous SystemGross CNS-22-01 Diagnosis: Uncal notchingUncal notching results from compression of the soft brain against the rigid edge of the tentoruim in cases of increased intracranial pressure.DGiM<  ""$&&,. 8CNS-23iCentral Nervous SystemrGross CNS-23-011)Diagnosis: Fresh ischemic or pale infarctTCoronal section of the brain with fresh ischemic or pale infarct. Note the liquifactive necrosis. The usual configuration that results from a vascualr accident in addition to its being confined to a specific blood vessel distribution is the triangular configuration, with the base towards the convexity and the apex towards the ventricle.DG/MB  ""$&&24 >CNS-24Central Nervous System H & E Stain CNS-24-019z!Diagnosis: Fresh ischemic infarcthFresh ischemic infarct. Notice the clear demarcation and separation of the normal from abnormal tissue.DGMF<  ""$&&,. 8CNS-25_Central Nervous System8Gross CNS-25-01 +Diagnosis: Organized (old) ischemic infarctHorizontal section of the brain with an organized (old) ischemic infarct. Note the loss of volume, asymmetry and the cavitation with discoloration that resulted.DG1MB  ""$&&24 >CNS-26Central Nervous System H & E Stain CNS-26-018%Diagnosis: Organized ischemic infarctuH & E stained section of an organized ischemic infarct - note the cavity formation with few strands of glial fibrils.DGxM<  ""$&&,. 8CNS-27Central Nervous SystemGross CNS-27-014Diagnosis: Hemorrhagic infarctoCoronal section of the brain with a hemorrhagic infarct - note how the process is following the gyral pattern.DG(OM B  ""$&&24 >CNS-28Central Nervous System H & E Stain CNS-28-019Diagnosis: Hemorrhagic infarctHemorrhagic / red infarct micros: multiple petechial hemorrhages that coalese, the neurons are with characteristic ischemic changes.DG8M<  ""$&&,. 8CNS-29Central Nervous SystemGross CNS-29-01/NDiagnosis: Medulla with an AVMVCross section of the medulla with an AVM, most of which appear to be intraparenchymal.DG)MB  ""$&&24 >CNS-30Central Nervous System H & E Stain CNS-30-019Diagnosis: AVMPAVM - note the different caliber and thickness of the vessels forming the lesionDG&MB  ""$&&24 >CNS-31Central Nervous System H & E Stain CNS-31-019Diagnosis: Cavernous hemangioma4Cavernous hemangioma, with very thin walled vessels.DGEM<  ""$&&,. 8CNS-32Central Nervous System Gross CNS-32-014Diagnosis: Meningitis, purulentpGross photo of purulent meningitis which refers to bacterial inflammation that is confined to the leptomeninges.DG]MB  ""$&&24 >CNS-33Central Nervous System! H & E Stain CNS-33-019Diagnosis: Memingitis, purulentTMeningitis, purulent, notice that the exudate is limited to the subarachnoid space.DG Mm<  ""$&&,. 8CNS-34Central Nervous System"Gross CNS-34-012Diagnosis: Chronic abscessCoronal section of the brain with a chronic abscess. Note the blurring of the gray white junction that results from cerebral edema, in addition to the increased volume of the left hemisphere as compared with the right.DG[M VD  ""$&&46 @CNS-35Central Nervous System# Special Stain CNS-35-019@Diagnosis: Chronic abscessTrichrome stained section of a chronic abscess. The greenish blue tissue represent the abscess capsule, the center is necrotic and to the outside of the capsule brain tissue with gliosis.DGkM <  ""$&&,. 8CNS-36Central Nervous System$Gross CNS-36-014"Diagnosis: Cryptococcal meningitis3Opaque meninges in case of cryptococcal meningitis.DGJDM B  ""$&&24 >CNS-37Central Nervous System% H & E Stain CNS-37-019~"Diagnosis: Cryptococcal meningitisbH& E stained section with cryptococcal infection. Note the paucity of the inflammatory component.DG.M B  ""$&&24 >CNS-38Central Nervous System& H & E Stain CNS-38-019"Diagnosis: Cryptococcal meningitisTClose up of cryptococcal meningitis - note the capsule that does not stain with H&E.DGBM <  ""$&&,. 8CNS-39Central Nervous System'Gross CNS-39-012Diagnosis: Multiple abscesses due to AspergillosisWHorizontal section of a brain with multiple hemorrhagic abscesses due to Aspergillosis.DGMB  ""$&&24 >CNS-40Central Nervous System( H & E Stain CNS-40-014;Diagnosis: Aspergillosis within the wall of a blood vessel Blood vessel with Aspergillosis within the wall. Aspergillosis have an affinity to invade blood vessel walls, giving the characteristic finding in immunocompromised patients suspected of having aspergillosis, of multiple hemorrhagic lesions.DG^M<  ""$&&,. 8CNS-41Central Nervous System)Gross CNS-41-01! 1Diagnosis: Multiple abcesses due to toxoplasmosisHorizontal section of a brain from an immunocompromised patient who was on high doses of steroids for the treament of rhemumatoid arthritis, with multiple abscesses, that proved to be due to Toxoplasma on microscopic examination.DGM\B  ""$&&24 >CNS-42Central Nervous System* H & E Stain CNS-42-019Diagnosis: Toxoplasma cyst High power view of a Toxoplasma cyst. Note that in the immediate vicinity no inflammatory response is present . However when the cyst ruptures an intense inflammatory response is usually noted.DG M<  ""$&&,. 8CNS-43Central Nervous System+Gross CNS-43-010XDiagnosis: Mass lesion obliterating the fourth ventricle that proved to be CysticercosisCoronal section of brainstem and cerebellum with a mass lesion obliterating the fourth ventricle that proved to be Cysticercosis. The patient presented with hydrocephalus, ( obstructive).DG@MCB  ""$&&24 >CNS-44PCentral Nervous System, H & E Stain CNS-44-019,Diagnosis: High power view of CysticercosisA longitudinal section through the head region of Cysticercosis illustrating the scolex with the hooks by which the organism attaches itself to the host.DGMF<  ""$&&,. 8CNS-45 Central Nervous System-hGross CNS-45-01!EDiagnosis: Bitemporal hemorrhagic necrosis due to Herpes encephalitisExternal appearance of the brain with bitemporal hemorrhagic necrosis, a distribution that is very characteristic of Herpes encephalitis.DG^MB  ""$&&24 >CNS-46Central Nervous System. H & E Stain CNS-46-019Diagnosis: Viral encephalitisvMicroglial shrub characteristic of viral infections of the brain. It is formed by accumulation of microglial cells. DGMkB  ""$&&24 >CNS-47Central Nervous System/ H & E Stain CNS-47-019SDiagnosis: Intranuclear inclusion of Cowdry type A in a case of herpes encephalitisTypical intranuclear inclusion Cowdry type A from a case of Herpes encephalitis. The intranuclear inclusions can be in neurons as well as glial elements.DGP|M<  ""$&&,. 8CNS-48Central Nervous System0Gross CNS-48-01!T,Diagnosis: Multiple lesions in a case of CMV{Horizontal section of a brain from an AIDS case with multiple necrotic lesions in the brain, clinically diagnosed with CMV.DG?LMB  ""$&&24 >CNS-49Central Nervous System1 H & E Stain CNS-49-019:Diagnosis: H&E from the previous case with a microabscess.ITissue necrosis and microglial cell proliferation form the microabscess. DGe;M-B  ""$&&24 >CNS-50Central Nervous System2 H & E Stain CNS-50-019Diagnosis: CMVH & E stained section with a large binucleated cell with intranuclear Cowdry type A inclusions. In CMV one can also encounter viral inclusions in the cytoplasm.DG M>  ""$&&.0 :CNS-51Central Nervous System3Autopsy CNS-51-01 Diagnosis: AnencephalypFrontal view from a case of anencephaly. Note the "frog-like eyes", low set ears, and thick protruding tongue. DGM >  ""$&&.0 :CNS-52Central Nervous System4UAutopsy CNS-52-01".Diagnosis: AnencephalyPosterior view of the previous case. Note the absence of the scalp and skull with exposure of the malformed remnants of the brain and meninges.DGUM>  ""$&&.0 :CNS-53Central Nervous System5Autopsy CNS-53-018Diagnosis: HoloprosencephalyThe scalp and skull are reflected with the exposure of the cranial cavity. Note the deformed cerebral hemispheres with the corpus callosum in the form of a horse shoe, surrounding the basal ganglia structures. In the posterior fossa membranous tissue is all that is apparent.DGPM<  ""$&&,. 8CNS-54Central Nervous System6Gross CNS-54-0177Diagnosis: Atrophy from a case with Alzheimer's disease#Coronal section of the brain at the level of the hippocampal formation. There is widening of the sulci, most apparent in the Sylvian fissure. Narrowing of the gyri, particularly the hippocampal formation. Ventricular dilatation affecting the lateral, third and temporal horns is present. DGMB  ""$&&24 >CNS-55Central Nervous System7d H & E Stain CNS-55-019.Diagnosis: Senile plaqueskTypical appearance of a plaque with amyloid center, surrounded by reactive astrocytes and microglial cells.DGMD  ""$&&46 @CNS-56Central Nervous SystemA8 Special Stain CNS-56-019Diagnosis: Neuritic plaqueIModified Bielschowsky silver stain illustrating numerous senile plaques. DGMD  ""$&&46 @CNS-57Central Nervous System9 Special Stain CNS-57-019!Diagnosis: Neurofibrillary tanglezModified Bielschowsky silver stain illustrating another hallmark of Alzheimer's disease: Neurofibrillary tangle formation.DGM <  ""$&&,. 8CNS-58Central Nervous System:Gross CNS-58-01.1Diagnosis: Parkinson's disease and normal controlSection of midbrain from a case of Parkinsons disease compared to a normal control. Note the intensity of the pigmentation of the substantia nigra in the control compared with the pallor of the S.N. from the Parkinsonian case.DGJM!B  ""$&&24 >CNS-59lCentral Nervous System; H & E Stain CNS-59-019*Diagnosis: Lewy body in a pigmented neuronhLewy body in a pigmented neuron from the substantia nigra from a case of idiopathic Parkinson's disease.DGM"3<  ""$&&,. 8CNS-60Central Nervous System<Gross CNS-60-018Diagnosis: Pick's diseaseThe characteristic pattern of atrophy involving the frontal and temporal lobe with the characteristic sparing of the posterior 2/3 of the superior temporal gyrus.DG&M#B  ""$&&24 >CNS-61Central Nervous System= H & E Stain CNS-61-019Diagnosis: Pick bodyiArrow : basophilic intracytoplasmic inclusion characteristically present in most cases of Pick's disease.DGM$<  ""$&&,. 8CNS-62Central Nervous System>Gross CNS-62-014Diagnosis: Glioma (astrocytoma)`Coronal section of a brain at the level of the head of the caudate nucleus, with an intrinsic mass in the right orbital surface of the frontal lobe. Note that it is not a destructive lesion but a mass producing lesion, thus representing a glioma. Gliomas grow by infiltration of the pre-existing structures. Also note the bulging into the ventricle.DG]M%B  ""$&&24 >CNS-63Central Nervous System? H & E Stain CNS-63-016Diagnosis: AstrocytomaH&E Stained section of a low grade astrocytoma. Note the eosinophilic processes, the monotony of the nuclei and microcyst formation. DGiM&<  ""$&&,. 8CNS-64GCentral Nervous System@Gross CNS-64-012"Diagnosis: Glioblastoma multiformeCoronal section of the brain at the level of the body of the caudate with a mass lesion that exhibit hemorrhage and necrosis with a pseudo- circumscription from the rest of the brain, a finding that can be encountered in glioblastomas.DGaPM'B  ""$&&24 >CNS-65Central Nervous SystemA H & E Stain CNS-65-019*Diagnosis: Glioblastoma Multiformae (GBM)H& E stained section of one of the most characteristic histologic features of GBM and that is of geographic necrosis (eosinophilic areas) with pseudopallisades that is made up of basophilic primitive or undifferentiated cells.DGo}M(6B  ""$&&24 >CNS-66lCentral Nervous SystemBb H & E Stain CNS-66-019Diagnosis: OligodendrogliomaH&E stained section of a typical oligodendroglioma; typical features include the monotonous round nuclei, perinuclear halo (fried egg), and calcifications. DGoM)A<  ""$&&,. 8CNS-67NCentral Nervous SystemAC Gross CNS-67-017 Diagnosis: MeningiomaSurgical specimen of a mengingioma. Generally meningiomas are globular masses with an attachment to the dura, size and location will influence the feasibility of surgical removal.DGM*B  ""$&&24 >CNS-68Central Nervous SystemD H & E Stain CNS-68-019Diagnosis: MeningiomagH&E stained section of a meningioma with whorl formation, fibrocollagenous septae and Psammoma bodies.DGM+j<  ""$&&,. 8CNS-69UCentral Nervous SystemEGross CNS-69-017Diagnosis: Metastic tumorCoronal section of a brain with a metastatic tumor. Usually metastatic tumors are located in the brain at the grey-white junction, and are sharply circumscribed from the surroundings. They can be single or multiple.DG%M,QB  ""$&&24 >CNS-70Central Nervous SystemF H & E Stain CNS-70-019$Diagnosis: Carcinomatous meningitis.A form of metastatic spread to the brain, small groups of tumor cells are located in the leptomeninges, most common primary tumor to spread in this manner is breast carcinoma.DG/M-4  "$ 0A-192-65 RespiratoryGross A-192-65-01 Diagnosis: Bronchopneumonia.Cut surface of left lung with bronchopneumoniaDG/M.4  "$ 0A-192-65 RespiratoryGross A-192-65-02!Diagnosis: BronchopneumoniaClose-up view of the same lung.DG5PM/B:   ""(* 6A-40-93Introductory BlocklGross A-40-93-015&zDiagnosis: At autopsy, there was an inferior wall myocardial infarct and rupture of the ventricle with a hemopericardium. RRupture of the heart. The point of rupture is the hemorrhagic area near the apex.DGdM0/:   ""(* 6A-40-93Introductory BlockGross A-40-93-021zDiagnosis: At autopsy, there was an inferior wall myocardial infarct and rupture of the ventricle with a hemopericardium. ?Multiple cross sections of the heart with infarct and rupture.DG5M1f:   ""(* 6A-40-93Introductory Block"Gross A-40-93-036zDiagnosis: At autopsy, there was an inferior wall myocardial infarct and rupture of the ventricle with a hemopericardium. vClose up of the rupture site. The defect in the heart is in the wall of the ventricle near the bottom of the picture.DG)M2@   "".0 <A-40-93Introductory BlockJ H & E Stain A-40-93-049zDiagnosis: At autopsy, there was an inferior wall myocardial infarct and rupture of the ventricle with a hemopericardium. A section of myocardium indicating infarct on the left with increased eosinophilia of muscle fibers and neutrophils between the muscle fibers contrasted with relatively normal fibers on the right.DGM3@   "".0 <A-40-93Introductory Block H & E Stain A-40-93-059zDiagnosis: At autopsy, there was an inferior wall myocardial infarct and rupture of the ventricle with a hemopericardium. Close up of eosinophilic myocardium with thick transverse bands ("contraction bands") in some of the cells near the center of the picture. This is a portion of the myocardium with a very early myocardial infarct.DGJ9M4 @   "".0 <A-40-93Introductory Block H & E Stain A-40-93-069zDiagnosis: At autopsy, there was an inferior wall myocardial infarct and rupture of the ventricle with a hemopericardium. *Myocardium with normal cross striations. DG6CM5:   ""(* 6A-35-94Introductory BlockGross A-35-94-01 Diagnosis: Thromboemboli3Kidney with infarct. The pale area is the infarct.DGJdM6:   ""(* 6A-35-94Introductory BlockGross A-35-94-02Diagnosis: Thromboemboli8Cut surface with infarct. The pale area is the infarct.DG3M7@   "".0 <A-35-94Introductory Block H & E Stain A-35-94-039Diagnosis: Thromboemboli/Photomicrograph of a normal area of the kidney.DG'vM8@   "".0 <A-35-94Introductory Block H & E Stain A-35-94-049Diagnosis: ThromboembolifInfarcted kidney. Photomicrograph to demonstrate the loss of cellular detail in the infarcted area. DGM9@   "".0 <A-58-93Introductory Block  H & E Stain A-58-93-019)Diagnosis: Tubular necrosis of the kidneyYLow power photomicrograph of the kidney. Note the vacuolated tubules in the upper right.DGM:9@   "".0 <A-58-93Introductory Block H & E Stain A-58-93-02h9)Diagnosis: Tubular necrosis of the kidneyAcute tubular necrosis. High power view demonstrating normal preserved tubular epithelium on the left and necrotic tubular epithelium on the right.DGM;>    "$$*, : S-2554-94Introductory Block Gross S-2554-94-017Diagnosis: Normal appendixNormal unopened appendix.DGM<>    "$$*, : S-2554-94Introductory BlockpGross S-2554-94-023Diagnosis: Normal appendixUNormal opened appendix. The slightly hemorrhagic regions are artifacts from surgery.DGIM=D    "$$02 @ S-2554-94Introductory Block- H & E Stain S-2554-94-039Diagnosis: Normal appendixwLow power photomicrograph of normal appendix demonstrating normal mucosa with lymphoid follicles and normal muscularis.DGM>>    "$$*, : S-2174-94Introductory Block[Gross S-2174-94-011Diagnosis: Acute appendicitisMAcute appendicitis. Note the hemorrhagic appearance of the external surface.DG.]M?>    "$$*, : S-2174-94Introductory BlockGross S-2174-94-027LDiagnosis: Acute appendicitisB Opened appendix. Note the marked necrosis of the mucosal lining.DGM@7D    "$$02 @ S-2174-94Introductory Blocki H & E Stain S-2174-94-039Diagnosis: Acute appendicitisHigh power photomicrograph of the wall of the appendix with abundant neutrophils. Neutrophils are not normally seen in the muscular wall of the appendix.DG+|MA@   "".0 <A-35-94Introductory Block H & E Stain A-35-94-059Diagnosis: Thromboemboli~Compare the cellular detail of the viable kidney in the left field to the loss of detail in the infarcted kidney on the right.DGDMBN  ""$&&:< J S-5712-87Electron MicrographyElectron Micrograph S-5712-87-01W9@Diagnosis: Cresentric Glomerulonephritis Immune-complex mediatedGlomerulonephritisDG zMCN  ""$&&:< J S-5712-87Electron MicrographyElectron Micrograph S-5712-87-029@Diagnosis: Cresentric Glomerulonephritis Immune-complex mediatedGlomerulonephritisDGeMDN  ""$&&:< J S-9833-89Electron MicrographyElectron Micrograph S-9833-89-019:Diagnosis: Cresentric Glomerulonephritis Anti-GBM mediatedGlomerulonephritisDGE6MEN  ""$&&:< J S-5904-83Electron Micrography Electron Micrograph S-5904-83-019 Diagnosis: Nemaline Rod Myopathy Muscle BiopsyDGYMFL  ""$&&:< HS-677-92Electron MicrographyfElectron Micrograph S-677-92-019)Diagnosis: Normal muscle (for comparison) Muscle BiopsyDGcMGP $$&((<> L S-14470-916Electron MicrographyElectron Micrograph S-14470-91-018'Diagnosis: Charcot-Marie-Tooth Syndrome Nerve BiopsyDGbMHP $$&((<> L S-14470-91Electron Micrography[Electron Micrograph S-14470-91-029'Diagnosis: Charcot-Marie-Tooth Syndrome Nerve BiopsyDG<@MIN  ""$&&:< J S-8859-91Electron Micrography\Electron Micrograph S-8859-91-019X(Diagnosis: Normal nerve (for comparison) Nerve BiopsyDGNPMJP $$&((<> L S-14039-88Electron Micrography Electron Micrograph S-14039-88-0191Diagnosis: Metastatic tumor Neuroendocrine origin8Undifferentiated Tumors Right Supraclavicular lymph nodeDGN MKP $$&((<> L S-14039-88Electron Micrographyu Electron Micrograph S-14039-88-0291Diagnosis: Metastatic tumor Neuroendocrine origin8Undifferentiated Tumors Right Supraclavicular lymph nodeDGkMLN  ""$&&:< J S-7941-89Electron Micrography Electron Micrograph S-7941-89-019-Diagnosis: Metastatic squamous cell carcinoma*Undifferentiated Tumors Pelvic lymph nodeDGhMMN  ""$&&:< J S-7941-89Electron Micrographyc Electron Micrograph S-7941-89-029-Diagnosis: Metastatic squamous cell carcinoma*Undifferentiated Tumors Pelvic lymph nodeDGMNN  ""$&&:< J S-9124-89Electron Micrography Electron Micrograph S-9124-89-01.Diagnosis: Adenocarcinoma0Undifferentiated Tumors Right upper lobe of lungDGMON  ""$&&:< J S-9124-89Electron MicrographyElectron Micrograph S-9124-89-027Diagnosis: Adenocarcinoma0Undifferentiated Tumors Right upper lobe of lungDG:MPN  ""$&&:< J S-2575-88Electron MicrographySElectron Micrograph S-2575-88-019Diagnosis: Mesothelioma6Undifferentiated Tumors Biopsy of intra-abdominal massDG4MQN  ""$&&:< J S-2575-88Electron MicrographyaElectron Micrograph S-2575-88-029Diagnosis: Mesothelioma6Undifferentiated Tumors Biopsy of intra-abdominal massDGMRL  ""$&&:< HA-104-90Electron MicrographybElectron Micrograph A-104-90-019GDiagnosis: Restrictive cardiomyopathy secondary to systemic amyloidosis MiscellaneousDG=MSL  ""$&&:< HA-104-90Electron MicrographyElectron Micrograph A-104-90-029GDiagnosis: Restrictive cardiomyopathy secondary to systemic amyloidosis MiscellaneousDGMTL  ""$&&:< HS-729-85Electron MicrographyElectron Micrograph S-729-85-019*Diagnosis: Herpes infectionMiscellaneous TEM routineDG MUL  ""$&&:< HV-886-83Electron MicrographyMElectron Micrograph V-886-83-010Diagnosis: Herpes infectionMiscellaneous Negative stainingDG.-MV<   ""(* 8 S-3365-69GastrointestinalrGross S-3365-69-018d6Diagnosis: Squamous cell carcinoma of the lower lip (Large squamous cell carcinoma of the lipDG-MW<   ""(* 8 S-3365-69GastrointestinalxGross S-3365-69-02W56Diagnosis: Squamous cell carcinoma of the lower lip Resected specimenDGzMX<   ""(* 8 S-3365-69GastrointestinalGross S-3365-69-0376Diagnosis: Squamous cell carcinoma of the lower lip 9Cross section of resected specimen (note the deep crater)DG MYB   "".0 > S-3365-69GastrointestinalJ H & E Stain S-3365-69-0496Diagnosis: Squamous cell carcinoma of the lower lip 1Lip lesion - keratinizing squamous cell carcinomaDGc5MZ%:   ""(* 6S-715-66GastrointestinalGross S-715-66-019jDiagnosis: Deeply invasive squamous cell carcinoma of the base of the tongue with microscopic pleomorphismEResected tongue (right) Attached radical neck (left) Mandible (above)DG1M[:   ""(* 6S-715-66)Gastrointestinal/Gross S-715-66-029jDiagnosis: Deeply invasive squamous cell carcinoma of the base of the tongue with microscopic pleomorphism#Close-up of ulcerated tongue lesionDGeM\@   "".0 <S-715-66Gastrointestinal H & E Stain S-715-66-039jDiagnosis: Deeply invasive squamous cell carcinoma of the base of the tongue with microscopic pleomorphismSquamous cell carcinomaDGPM]:   (* 6A-65-65GastrointestinalAutopsy A-65-65-01!3Diagnosis: Squamous cell carcinoma of the esophagus:Starvation due to squamous cell carcinoma of the esophagusDGhjM^8   &( 4A-65-65GastrointestinalGross A-65-65-02!3Diagnosis: Squamous cell carcinoma of the esophagus5Severe constriction of the esophagus due to carcinomaDG<4M_8   &( 4A-65-65GastrointestinalUGross A-65-65-03 3Diagnosis: Squamous cell carcinoma of the esophagus9Close-up view of the constriction of the esophagus openedDG[M`8   &( 4A-65-65Gastrointestinal\Gross A-65-65-0463Diagnosis: Squamous cell carcinoma of the esophagus4Cross sections of esophagus through the constrictionDG$Ma<   ""(* 8 S-2804-65Gastrointestinal!sGross S-2804-65-019:Diagnosis: Chronic peptic ulcer)Large chronic peptic ulcer of the stomachDGpMb<   ""(* 8 S-2804-65Gastrointestinal"Gross S-2804-65-029Diagnosis: Chronic peptic ulcerClose-up view of the ulcerDG/Mc<   ""(* 8 S-2804-65Gastrointestinal#RGross S-2804-65-038NDiagnosis: Chronic peptic ulcer9Cross section of the ulcer - note the depth of ulcerationDG&Mh:   ""(* 6S-321-68Gastrointestinal(Gross S-321-68-019HDiagnosis: Gastric leiomyoma 1A gastric leiomyoma evident in the opened stomachDG hMi:   ""(* 6S-321-68Gastrointestinal)Gross S-321-68-029$Diagnosis: Gastric leiomyoma "Cross section of gastric leiomyomaDGaMj:   ""(* 6S-115-69Gastrointestinal*Gross S-115-69-0196(Diagnosis: Adenocarcinoma of the stomach5Small ulcerated gastric carcinoma - gastric resectionDGMk:   ""(* 6S-115-69Gastrointestinal+Gross S-115-69-029(Diagnosis: Adenocarcinoma of the stomach!Close-up of the gastric carcinomaDGAMl-<   ""(* 8 S-7602-72Gastrointestinal,Gross S-7602-72-016qDiagnosis: Deeply infiltrating, spreading, poorly differentiated adenocarcinoma of the stomach (linitis plastica)DOpened stomach with infiltrating gastric cancer ('linitis plastica")DG{Mm<   ""(* 8 S-7602-72Gastrointestinal-rGross S-7602-72-029qDiagnosis: Deeply infiltrating, spreading, poorly differentiated adenocarcinoma of the stomach (linitis plastica)'Close-up of the involved stomach tissueDG#&Mnl:   (* 6A-26-66Gastrointestinal.Autopsy A-26-66-01$Diagnosis: Hemorrhagic infarction of the terminal portion of the jejunum and first portion of the ileum due to mesenteric vein thrombosis; portal vein thrombosis and severe portal cirrhosis of the liver.+Normal bowel at top, infarcted bowel bottomDG_DMob8   &( 4A-26-66Gastrointestinal/Gross A-26-66-028Diagnosis: Hemorrhagic infarction of the terminal portion of the jejunum and first portion of the ileum due to mesenteric vein thrombosis; portal vein thrombosis and severe portal cirrhosis of the liver.#Resected portion of infarcted bowelDGZMp"<   ""*, 8A-171-60Gastrointestinal0Autopsy A-171-60-019Diagnosis: Hemorrhagic infarction of the small bowel due to an adhesive band extending from the sigmoid colon to the mesentery.+Infarct of small bowel due to adhesive bandDG#GMq><   ""*, 8A-171-60Gastrointestinal1Autopsy A-171-60-02*Diagnosis: Hemorrhagic infarction of the small bowel due to an adhesive band extending from the sigmoid colon to the mesentery.GClose-up of the infarcted bowel with the adhesive band clearly apparentDG 0Mr<   ""(* 8 S-1145-64Gastrointestinal2Gross S-1145-64-01(Diagnosis: Adenocarcinoma of the jejunum1Segment of jejunum with constriction by carcinomaDG@#Ms<   ""(* 8 S-1145-64Gastrointestinal3Gross S-1145-64-028l(Diagnosis: Adenocarcinoma of the jejunum&Opened bowel with complete obstructionDG>Mt:   ""(* 6A-141-61Gastrointestinal4Gross A-141-61-01RDiagnosis: Intussusception due to osteogenic sarcoma metastatic to the small bowel&Unopened small bowel - intussesceptionDG Mu:   ""(* 6A-141-61Gastrointestinal5Gross A-141-61-028RDiagnosis: Intussusception due to osteogenic sarcoma metastatic to the small bowel/Cross section of intussesception of small bowelDG?Mv>   "$$*, : S-14009-88lGastrointestinal6oGross S-14009-88-01Diagnosis: Acute appendicitisAcute appendicitisDG Mw:   ""(* 6S-339-61Gastrointestinal7Gross S-339-61-015 GDiagnosis: Mucocele of the appendix with acute and chronic inflammation!Unopened mucocele of the appendixDG^Mx:   ""(* 6S-339-61@Gastrointestinal8Gross S-339-61-0278GDiagnosis: Mucocele of the appendix with acute and chronic inflammationOpened mucocele of the appendixDG>My<   ""(* 8 S-2787-61Gastrointestinal9Gross S-2787-61-016P*Diagnosis: Carcinoid tumor of the appendix*Carcinoid tumor at the tip of the appendixDGWMz<   ""(* 8 S-2787-61Gastrointestinal:Gross S-2787-61-024*Diagnosis: Carcinoid tumor of the appendix9Cross section of the appendix through the carcinoid tumorDG M{B   "".0 > S-2787-61Gastrointestinal;Y H & E Stain S-2787-61-039*Diagnosis: Carcinoid tumor of the appendix*Microscopic of carcinoid tumor of appendixDGU+M|6   &( 2A-8-62Gastrointestinal<Gross A-8-62-016 .Diagnosis: Diverticulosis of the sigmoid colon;Typical sigmoid diverticula - incidental finding at autopsyDGSM}>   "$$*, : S-12576-94Gastrointestinal=ZGross S-12576-94-018+Diagnosis: Diverticula of the sigmoid colon@Opened sigmoid colon with thickening of the wall and diverticulaDG0M~>   "$$*, : S-12576-94Gastrointestinal>Gross S-12576-94-029+Diagnosis: Diverticula of the sigmoid colon4Close-up view of the diverticula and wall thickeningDG^M>   "$$*, : S-12576-94Gastrointestinal?.Gross S-12576-94-038@+Diagnosis: Diverticula of the sigmoid colon&Cross section with diverticulum in fatDGyM<   ""(* 8 S-6211-70Gastrointestinal@nGross S-6211-70-017/Diagnosis: Adenoma (polyp) of the sigmoid colon)Pedunculated tubular adenoma of the colonDGc_MB   "".0 > S-6211-70GastrointestinalA H & E Stain S-6211-70-02!/Diagnosis: Adenoma (polyp) of the sigmoid colonLow power microscopicDG:MB   "".0 > S-6211-70GastrointestinalBa H & E Stain S-6211-70-038/Diagnosis: Adenoma (polyp) of the sigmoid colonDHigher power microscopic Normal on the right - Atypical on the leftDG M>   "$$*, : S-12826-94GastrointestinalGross S-12826-94-015DDiagnosis: Warthin's Tumor (Cystadenoma papillomatosum papilliferum)$This 3 cm. mass is a Warthin's tumorDG}+M>   "$$*, : S-12826-945Gastrointestinal Gross S-12826-94-026DDiagnosis: Warthin's Tumor (Cystadenoma papillomatosum papilliferum)9Close-up of the surface made by cutting through the tumorDGkMD   "$$02 @ S-12826-94VGastrointestinal \ H & E Stain S-12826-94-039DDiagnosis: Warthin's Tumor (Cystadenoma papillomatosum papilliferum)Microscopic of Warthin's tumorDG\`M<   ""(* 8 S-9129-94Gastrointestinal Gross S-9129-94-013Diagnosis: Pleomorphic adenoma .Parotid gland with a small pleomorphic adenomaDGN S-9129-94Gastrointestinal H & E Stain S-9129-94-049Diagnosis: Pleomorphic adenoma $Microscopic of a pleomorphic adenomaDGuM@   "",. < S-5277-94GastrointestinallClinical S-5277-94-01\$Diagnosis: Large pleomorphic adenoma+Large pleomorphic adenoma 15cm. in diameterDGSM<   ""(* 8 S-5277-94Gastrointestinal`Gross S-5277-94-028$Diagnosis: Large pleomorphic adenomaOver-all view of resected tumorDGRM<   ""(* 8 S-5277-94GastrointestinaleGross S-5277-94-038$Diagnosis: Large pleomorphic adenoma*Cross section of large pleomorphic adenomaDGRM>   "$$*, : S-12705-94Gastrointestinal.Gross S-12705-94-017H9Diagnosis: Mucoepidermoid carcinoma of the parotid gland -Parotid gland with a mucoepidermoid carcinomaDGIMD   "$$02 @ S-12705-94Gastrointestinal H & E Stain S-12705-94-0299Diagnosis: Mucoepidermoid carcinoma of the parotid gland 'Microscopic of mucoepidermoid carcinomaDGE4M<   ""(* 8 S-1189-72GastrointestinalCHGross S-1189-72-018N.Diagnosis: Large sessile adenoma of the rectum-Large sessile (villous) adenoma of the rectumDGsM<   ""(* 8 S-1571-62GastrointestinalDGross S-1571-62-019:+Diagnosis: Multiple polyposis of the colonMultiple polyposis of the colonDG~M<   ""(* 8 S-1571-62GastrointestinalEGross S-1571-62-029h+Diagnosis: Multiple polyposis of the colonClose-up of polypsDGm>M>   "$$*, : S-12384-94GastrointestinalFSGross S-12384-94-0181Diagnosis: Ulcerating adenocarcinoma of the colon:Ulcerating adenocarcinoma of the colon (4 cm. in diameter)DG)M>   "$$*, : S-12384-94GastrointestinalGGross S-12384-94-029r1Diagnosis: Ulcerating adenocarcinoma of the colon.Close-up view of the ulcerating adenocarcinomaDG#hMD   "$$02 @ S-12384-94GastrointestinalH H & E Stain S-12384-94-0391Diagnosis: Ulcerating adenocarcinoma of the colon.Adenocarcinoma on the left Normal on the rightDGeM>   "$$*, : S-13288-94GastrointestinalIGross S-13288-94-018=Diagnosis: Adenocarcinoma of the colon with signet ring cells!Opened colon with adenocarcinoma DGkbM>   "$$*, : S-13288-94LGastrointestinalJGross S-13288-94-029:=Diagnosis: Adenocarcinoma of the colon with signet ring cells*Close-up view of the adenocarcinoma lesionDGM>   "$$*, : S-13288-94#GastrointestinalKOGross S-13288-94-037=Diagnosis: Adenocarcinoma of the colon with signet ring cells+Cross section with tumor extending into fatDGd`MD   "$$02 @ S-13288-94GastrointestinalL H & E Stain S-13288-94-049=Diagnosis: Adenocarcinoma of the colon with signet ring cellsSignet ring cellsDG-zM>   "$$*, : S-16765-93GastrointestinalMGross S-16765-93-019JDiagnosis: Crohn's disease)Crohn's disease - note the thickened wallDG9cM>   "$$*, : S-16765-93GastrointestinalNoGross S-16765-93-029<Diagnosis: Crohn's disease$Crohn's disease - linear ulcerationsDGZMD   "$$02 @ S-16765-93 GastrointestinalO[ H & E Stain S-16765-93-039Diagnosis: Crohn's diseaseCrohn's disease - granulomasDGsfM>   "$$*, : S-14094-875GastrointestinalP`Gross S-14094-87-019n>Diagnosis: Chronic ulcerative colitis with recent exacerbation!Ulcerative colitis - opened bowelDG M>   "$$*, : S-14094-87GastrointestinalQGross S-14094-87-028>Diagnosis: Chronic ulcerative colitis with recent exacerbationUlcerated surface of colonDGTMD   "$$02 @ S-14094-879GastrointestinalR1 H & E Stain S-14094-87-039>Diagnosis: Chronic ulcerative colitis with recent exacerbation!Ulcerative colitis - cyst abscessDGhM>   "$$*, : S-17565-93rGastrointestinalSGross S-17565-93-018#Diagnosis: Pseudomembranous colitis?Over-all view of the colon opened with pseudomembranous colitisDG7M>   "$$*, : S-17565-93cGastrointestinalTtGross S-17565-93-029#Diagnosis: Pseudomembranous colitis3Pseudomembranous colitis : close-up of colon mucosaDGMD   "$$02 @ S-17565-93sGastrointestinalU H & E Stain S-17565-93-038#Diagnosis: Pseudomembranous colitis4Pseudomembrane (necrotic mucosa) on surface of bowelDG'M:   ""(* 6A-107-59rGastrointestinalV\Gross A-107-59-018#Diagnosis: Hemorrhagic pancreatitisAcute hemorrhagic pancreatitisDG0M:   ""(* 6A-107-59GastrointestinalWGross A-107-59-027#Diagnosis: Hemorrhagic pancreatitis Severe fatty change of the liverDGM>   "$$*, : S-10847-94GastrointestinalXGross S-10847-94-016)Diagnosis: Adenocarcinoma of the pancreas,Adenocarcinoma of the pancreas - cut surfaceDGzMD   "$$02 @ S-10847-94GastrointestinalY H & E Stain S-10847-94-029)Diagnosis: Adenocarcinoma of the pancreasMicroscopic of adenocarcinomaDG& `6 &( 2HEM-1 Hematology Wright StainHEM-1-019@Diagnosis: Peripheral blood: Normochromic, normocytic red cellsth paraneoplastic syndromeDPhotomicrograph of tumor with evidenceDG `6 &( 2HEM-2 Hematology Special StainHEM-2-019*GDiagnosis: Peripheral blood: Spherocytes - Autoimmune hemolytic anemia 0f_  _`_ f_ fDGq"`6 &( 2HEM-3 Hematology Wright StainHEM-3-019*@Diagnosis: Peripheral blood: Howell-Jolly bodies and target cellDG}`6 &( 2HEM-4 Hematology Wright StainHEM-4-0189Diagnosis: Peripheral blood: Rouleaux - multiple myelomaDG!`6 &( 2HEM-6 Hematology Wright StainHEM-6-019ODiagnosis: Peripheral blood: Reactive lymphocytes - infectious mononucleosisic syndromeDPhotomicrograph of tumor with evidenceDG`)`6 &( 2HEM-7 Hematology Wright StainHEM-7-019GDiagnosis: Peripheral blood: Bilobate neutrophil - Pelger Huet anomalyDGQXM*  &HEM-7 HematologyHEM-7-019GDiagnosis: Peripheral blood: Bilobate neutrophil - Pelger Huet anomalyDGCG`6 &( 2HEM-8 Hematology Special StainHEM-8-0183Diagnosis: Normal bone marrow aspirate - high power Wright stainDGRzM4 $& 0HEM-9 Hematology H & E StainHEM-9-0191Diagnosis: Normal bone marrow biopsy - high powerDG|`8  (* 4HEM-10 Hematology Wright Stain HEM-10-018^YDiagnosis: Peripheral blood: Hypochromic microcytic red cells - iron deficiency anemiaDG `8  (* 4HEM-182 Hematology Wright Stain HEM-18-017*NDiagnosis: Peripheral Blood: Blast with Auer rod - acute myelogenous leukemiaDGs{`8  (* 4HEM-12i Hematology d Wright Stain HEM-12-015]Diagnosis: Bone marrow aspirate - high power: giant neutrophilic band - Megaloblastic anemiahotomicrograph of tumor with evidenceDG4`6  &( 2HEM-13c Hematology H & E Stain HEM-13-019ADiagnosis: Bone marrow biopsy - high power: Megaloblastic anemianomaly 0f_  _`_ f_ fDGz`8  (* 4HEM-14 Hematology Wright Stainn HEM-14-019 ]Diagnosis: Peripheral blood: Target cells and intracellular crystals - hemoglobin SC diseaseDG<`8  (* 4HEM-151 Hematology Wright Stain HEM-15-019 fDiagnosis: Peripheral blood: Sickle cells, target cells, and Howell- Jolly body - sickle cell diseaseDG``8  (* 4HEM-161 Hematology Wright Stain HEM-16-018RDiagnosis: Peripheral blood: Blasts and lymphocyte - acute lymphoblastic leukemiaDG\V`8  (* 4HEM-17 Hematology Wright Stain HEM-17-019XADiagnosis: Peripheral blood: Blasts - acute myelogenous leukemiaDGxi`8  (* 4HEM-25 Hematology Wright Stain HEM-25-019LDiagnosis: Peripheral blood: Lymphocytosis - chronic lymphocytic leukemiaDG`8  (* 4HEM-193 Hematology Special Stain HEM-19-017KDiagnosis: Bone marrow aspirate - high power: acute myelogenous leukemia Wright stainiahotomicrograph of tumor with evidenceDGd`6  &( 2HEM-20 Hematology H & E Stain HEM-20-019GDiagnosis: Bone marrow biopsy - high power: acute myelogenous leukemia 0f_  _`_ f_ fDG`8  (* 4HEM-21 Hematology Special Stain HEM-21-019:GDiagnosis: Bone marrow aspirate: acute promyelocytic leukemia (AML-M3) Wright stainiseaseDG1`8  (* 4HEM-22 Hematology% Special Stain HEM-22-018]Diagnosis: Bone marrow aspirate - high power: acute monocytic leukemia with maturation (M5b) Wright stainDG%`8  (* 4HEM-23 Hematology Special Stain HEM-23-019iDiagnosis: Bone marrow aspirate - high power: acute myelogenous leukemia - myeloperoxidase stain (MPO)Myeloperoxidase stainDGg`8  (* 4HEM-46 Hematology.o Wright Stain HEM-46-019ADiagnosis: Bone marrow aspirate: plasma cells - multiple myelomaic esterase stain (NSE)Non-specific stainDG!`6 &( 2HEM-5 Hematology Wright StainHEM-5-0180EDiagnosis: Peripheral blood: Schistocytes and thrombocytopenia - TTPDGP`6  &( 2HEM-26 Hematology H & E Stain HEM-26-019LdDiagnosis: Bone marrow biopsy: interstitial lymphocytic aggregates - chronic lymphocytic leukemiaE)Non-specific esterase staiDG"`8  (* 4HEM-27[ Hematology Wright Stain] HEM-27-0191Diagnosis: Peripheral blood: hairy cell leukemiamyelogenous leukemia 0f_  _`_ f_ fDG``6  &( 2HEM-28 Hematology H & E Stain HEM-28-019HDiagnosis: Bone marrow biopsy: diffuse infiltrate - hairy cell leukemia) Wright stainiseaseDG.4`8  (* 4HEM-29 Hematology Special Stain HEM-29-019 SDiagnosis: Bone marrow aspirate smear - high power, Trap stain; hairy cell leukemia Trap stainWright stainDG`6  &( 2HEM-30L Hematologyc H & E Stain HEM-30-0196Diagnosis: Normal lymphoid tissue - low power: tonsil myelogenous leukemia - myeloperoxidase stain (MPO)Myeloperoxidase stainDG`6  &( 2HEM-31 Hematology H & E Stain HEM-31-0196Diagnosis: Lymph node - low power: Follicular lymphomanous leukemia @ ^J @ Tool_Objects_S0DG`6  &( 2HEM-32p Hematology H & E Stain HEM-32-019TDiagnosis: Lymph node - high power: Non-Hodgkins lymphoma, small cleaved cell type?Sba2`/8 ިs x =hD=hJ=hF<.DG`6  &( 2HEM-33d Hematology! H & E Stain HEM-33-019YDiagnosis: Lymph node - high power: Non-Hodgkins lymphoma - large non-cleaved cell typeHn?.Ԩ?.֨?.ҨsLN^ _O NDGT`6  &( 2HEM-34 Hematology" H & E Stain HEM-34-019ZDiagnosis: Bone marrow biopsy: paratrabecular lymphocytic aggregate - follicular lymphomaBg/HoSPONugJ+qNuag k#DG`6  &( 2HEM-35 Hematology# H & E Stain HEM-35-019MDiagnosis: Lymph node - high power: Non-Hodgkins lymphoma - immunoblastic(U)@XHx gHz`Hzg8ag 0@Dl8DG`6  &( 2HEM-363 Hematology$ H & E Stain HEM-36-019dDiagnosis: Lymph node - high power: Reed Sternberg cell - Nodular sclerosing type Hodgkins diseasepA rh2.PSP rXP"<DG1`8  (* 4HEM-37 Hematology% Wright Stain HEM-37-018kDiagnosis: Peripheral blood - high power: dysplastic, hypogranular neutrophil - myelodysplastic syndrome08 U@?J.g0<aDG`8  (* 4HEM-38 Hematology& Wright Stain HEM-38-019^nDiagnosis: Bone marrow aspirate - high power: ringed sideroblasts - refactory anemia with ringed sideroblastsvJg4g(J+og"DG7`8  (* 4HEM-39D Hematology' Wright Stain= HEM-39-018nDiagnosis: Bone marrow aspirate - high power: myelodysplastic syndrome - Refractory anemia with excess blastsDWDo/+vHx (6Diagnosis: Adrenal hyperplasia with Cushings syndromeBSurfaces made by cutting of the adrenal glands - Cushing's diseaseDGM2   " .S-877-72 Endocrine nGross S-877-72-014\SDiagnosis: Functioning adrenal cortical adenomas associated with Cushings syndromeAdrenal cortical adenomaDGhM0   ,A-97-73 Endocrine _Gross A-97-73-010Diagnosis: Pheochromocytoma of the adrenal gland)Enlarged adrenal gland (Pheochromocytoma)DG^M0   ,A-97-73 Endocrine ZGross A-97-73-0250Diagnosis: Pheochromocytoma of the adrenal glandASurfaces made by cutting of the adrenal gland - PheochromocytomaDG4M6  $& 2A-97-73 EndocrineD H & E Stain A-97-73-0390Diagnosis: Pheochromocytoma of the adrenal gland'Microscopic picture of pheochromocytomaDG8~MJ0  " ,REP-1 ReproductiveGrossREP-1-01 Diagnosis: Condyloma acuminataCondyloma acuminata due to human papillomavirus surrounding the anus in a two year old. Note the multiple warty excrescences. Contributed by Dr. Victoria Nichols-Johnson, OB/GYN Department. DGM:  &( 6 S-16518-94 ReproductiveGross S-16518-94-01!b)Diagnosis: Carcinoma-in-situ of the vulvaCarcinoma-in-situ of the vulvaDG5M>  *, : S-16518-94 ReproductiveClinical S-16518-94-02!)Diagnosis: Carcinoma-in-situ of the vulvaKClinical photograph taken during vulvectomy for carcinoma-in-situ of vulva.DG "M>  *, : S-16518-94 ReproductiveClinical S-16518-94-03!)Diagnosis: Carcinoma-in-situ of the vulva,Clinical photograph taken after vulvectomy. DG$M:  &( 6 S-16518-94e Reproductivee_Gross S-16518-94-04")Diagnosis: Carcinoma-in-situ of the vulva5Vulva with carcinoma-in-situ submitted to pathology. DGZ@M@  ,. < S-16518-94 Reproductive H & E Stain S-16518-94-05")Diagnosis: Carcinoma-in-situ of the vulva=Full thickness involvement of carcinoma-in-situ of the vulva.DG$MZ@  ,. < S-16518-94 Reproductive H & E Stain S-16518-94-06!)Diagnosis: Carcinoma-in-situ of the vulvaClose-up of VIN III, showing extensive mitotic activity at least halfway up the epithelial layer. Note the lack of flattening and maturation of the cells as they become superficial.DGrM8  $& 4 S-2102-96 ReproductiveGross S-2102-96-018-Diagnosis: Vulva with squamous cell carcinomaKVulva with squamous cell carcinoma showing exophytic nature of the cancer. DG|RM>  *, : S-2102-96 Reproductive H & E Stain S-2102-96-029-Diagnosis: Vulva with squamous cell carcinomaPSquamous cell carcinoma showing the tumor infiltrating into the inflamed stroma.DGM>  *, : S-2102-96 Reproductive H & E Stain S-2102-96-039-Diagnosis: Vulva with squamous cell carcinoma;Characteristic malignant squamous cells with marked atypia.DGhMq8 (* 4REP-2 Reproductive Special StainREP-2-019!Diagnosis: Neisseria gonorrhoeae.Neisseria gonorrhoeae. Note the biscuit-shaped or kidney bean-shaped gram negative intracellular diplococci characteristic of Neisseria species [as well as Moraxella (previously called Branhamella species) Gram stain]. DGhMP4 $& 0REP-3 Reproductive ClinicalREP-3-01"Diagnosis: Bacterial vaginosisBacterial vaginosis. Note the lack of surrounding inflammation of the vulva but the presence of a thin white profuse discharge. Contributed by Dr. Victoria Nichols-Johnson, OB/GYN Department. DGr=M8 (* 4REP-3 Reproductive Special StainREP-3-029LDiagnosis: Bacterial vaginosisVaginal epithelial cell with borders obscured by bacteria ("clue cell"). This is characteristic of bacterial vaginosis (Gram stain).DGPM8 (* 4REP-3 ReproductiveW Special StainREP-3-039.Diagnosis: Bacterial vaginosismNormal vaginal epithelial cell seen with a few gram positive bacilli (most likely lactobacilli) (Gram stain).DG$M8 (* 4REP-4 Reproductive Special StainREP-4-018!Diagnosis: Trichomonas vaginalis :Trichomonas vaginalis (arrows); note flagella (wet mount).DGf%M8 (* 4REP-4 Reproductive Special StainREP-4-029!Diagnosis: Trichomonas vaginalis TTrichomonas vaginalis adjacent to a neutrophil; note flagellum (arrows) (Gram stain)DGM48 (* 4REP-5 Reproductive Special StainREP-5-01'"!Diagnosis: Chlamydia trachomatis Chlamydia trachomatis (the two apple green cytoplasmic inclusions) in the red background of mouse McCoy cells from tissue culture (fluorescent antibody stain).DGM8  $& 4 S-3877-94 ReproductiveGross S-3877-94-01"d3Diagnosis: Nabothian retention cysts of the cervix ,Nabothian retention cysts of cervix (arrow) DG#M>  *, : S-3877-94 Reproductive H & E Stain S-3877-94-0293Diagnosis: Nabothian retention cysts of the cervix -Dilated glands of nabothian retention cysts. DGJM>  *, : S-3877-94 Reproductive H & E Stain S-3877-94-0393Diagnosis: Nabothian retention cysts of the cervix 5Dilated glands of nabothian retention cysts-close up.DGmM6  $& 2S-620-69 ReproductiveGross S-620-69-018|2Diagnosis: Nabothian retention cysts of the cervix@Another example of multiple nabothian retention cysts of cervix.DGZMB  .0 > PM-1331-96 Reproductive Special Stain PM-1331-96-018Diagnosis: Herpes simplex -Pap stain. Multinucleated giant cell characteristic of Herpes in a cervical scraping. Note the "eggs in a basket" characteristic in which the nuclei are crowded into the center and the cytoplasm is minimal as well as the glassy nuclei that are characteristic of Herpes simplex (Papanicolaou stain). DG7MB  .0 > PM-1331-96 Reproductive Special Stain PM-1331-96-028Diagnosis: Herpes simplex |Pap stain. Multinucleated giant cell characteristic of Herpes. Note the red intranuclear inclusions (Papanicolaou stain). DGmMB  .0 > P-32344-92 Reproductive Special Stain P-32344-92-019| P-36020-96 Reproductive Special Stain P-36020-96-019Diagnosis: KoilocyteJPap stain. Koilocyte in the center (arrow). This koilocytic cell is suggestive of human papillomavirus because: (a) The nucleus is larger than expected in a cell of this maturation; (b) the wide perinuclear clearing; and (c) the dense halo of cytoplasm on the cell perimeter. This cell should be compared to a more normal cell (N) near the periphery showing a normal nuclear to cytoplasmic ratio and no dense halo of cytoplasm. Although there is a suggestion of perinuclear clearing in this normal cell, it does not fulfill the other criteria for a koilocyte (Papanicolaou stain). DG gMKB  .0 > P-36020-96 Reproductive Special Stain P-36020-96-029Diagnosis: KoilocytePap stain. Koilocytosis in two keratinized squamous cells. Note the high nuclear to cytoplasmic ratio, the perinuclear clearing, and the dense halo of cytoplasm (Papanicolaou stain). DGoM@  ,. < S-14621-94 Reproductive H & E Stain S-14621-94-019Diagnosis: HPV infection?Cervical biopsy with HPV infection with arrows on koilocytosis.DGWMB  .0 > P-24969-91 Reproductive Special Stain P-24969-91-019b9Diagnosis: Mild to moderate dysplasia in a cervical smear P-33017-96 Reproductive! Special Stain P-33017-96-014/Diagnosis: Keratinizing squamous cell carcinomalPap stain. Keratinizing squamous cell carcinoma. Surrounding the central cell is the necrotic keratin ("tumor diathesis") characteristic of squamous cell carcinoma. In the center is a keratinized cell (because of the orange color) which is a cancer cell (because of the large, irregular nucleus and clumped chromatin characteristic of squamous cell carcinoma) DGϕMB  .0 > P-33017-96 Reproductive" Special Stain P-33017-96-02'V/Diagnosis: Keratinizing squamous cell carcinomaPap stain. A cluster of keratinized squamous cell carcinoma cells. Note the high nuclear to cytoplasmic ratio and the disorganized architecture (normally a cluster of keratinized squamous cells would look more organized and not crowded) DG7MB  .0 > P-27415-90 Reproductive# Special Stain P-27415-90-019"Diagnosis: Squamous cell carcinomaFSquamous cell carcinoma in a cervical scraping (Papanicolaou stain) DGNM8  $& 4 S-1341-93 ReproductiveH$Gross S-1341-93-017"Diagnosis: Squamous cell carcinoma4Cervix as viewed on end with squamous cell carcinomaDGW!M8  $& 4 S-1341-93 Reproductives%nGross S-1341-93-02t#F"Diagnosis: Squamous cell carcinoma8Cervix and uterus cut open showing the cervical cancer. DG|M 8  $& 4 S-1341-93 Reproductivee&eGross S-1341-93-03c7"Diagnosis: Squamous cell carcinomaClose-up of the cancer DGM >  *, : S-1341-93 Reproductivet' H & E Stain S-1341-93-04 9"Diagnosis: Squamous cell carcinoma#Squamous cell carcinoma with atypiaDGvM >  *, : S-1341-93 Reproductiveo(c H & E Stain S-1341-93-05r9"Diagnosis: Squamous cell carcinoma9Close-up. Note the abnormal mitotic figure in the centerDGtM >  *, : S-1341-93 Reproductived)c H & E Stain S-1341-93-06 9"Diagnosis: Squamous cell carcinomaELymph node invasion of squamous cell carcinoma (bottom half of field)DGFM >  *, : S-3668-94 Reproductives*g H & E Stain S-3668-94-01n99Diagnosis: Invasive squamous cell carcinoma of the cervixkAnother invasive squamous cell carcinoma of the cervix with eosinophilic squamous cells in large clusters. DGtM>  *, : S-3668-94 Reproductivea+ H & E Stain S-3668-94-02x99Diagnosis: Invasive squamous cell carcinoma of the cervixClose-upDGGM:  &( 6 S-11644-94t Reproductive, Gross S-11644-94-018$Diagnosis: Adenomyosis of the uterus1Adenomyosis of the uterus showing enlarged uterusDGXM:  &( 6 S-11644-94 Reproductive-eGross S-11644-94-028$Diagnosis: Adenomyosis of the uterusMAdenomyosis with small cystic or hemorrhagic foci (arrows) in the myometrium DGysM@  ,. < S-11644-94 Reproductive. H & E Stain S-11644-94-039|$Diagnosis: Adenomyosis of the uterusPLow power field showing endometrial stroma and glands (arrow) within myometrium DGM@  ,. < S-11644-94d Reproductiveh/t H & E Stain S-11644-94-049$Diagnosis: Adenomyosis of the uterus7Glands and endometrial stroma within myometrium (arrow)DGZM:  &( 6 S-13309-94n Reproductivew0 Gross S-13309-94-01)Diagnosis: Multiple leiomyomas?Uterus and ovaries with uterus distorted by multiple leiomyomasDGM:  &( 6 S-13309-94c Reproductivet1nGross S-13309-94-02#Diagnosis: Multiple leiomyomasCut surfaces of the leiomyomasDGxwM:  &( 6 S-13309-940 Reproductive2Gross S-13309-94-03&(Diagnosis: Multiple leiomyomasHClose-up. Note the apparent encapsulation and nodular white appearance.DGAzM@  ,. < S-13309-94f Reproductive3r H & E Stain S-13309-94-049Diagnosis: Multiple leiomyomas$Smooth muscle cells of the leiomyomaDGBiM:  &( 6 S-18109-92 Reproductivel4aGross S-18109-92-019'Diagnosis: Endometrium with hyperplasia2Opened uterus showing endometrium with hyperplasiaDG9M:  &( 6 S-18109-92o Reproductiver5tGross S-18109-92-029'Diagnosis: Endometrium with hyperplasia0Close-up showing hyperplasia of the endometrium.DG(M@  ,. < S-18109-92 Reproductive6 H & E Stain S-18109-92-039'Diagnosis: Endometrium with hyperplasia\Simple hyperplasia of the endometrium characterized by round, simple glands of various sizesDGM@  ,. < S-18109-92 Reproductive7 H & E Stain S-18109-92-049'Diagnosis: Endometrium with hyperplasiaVComplex hyperplasia of the endometrium showing budding formation of the glands (arrow)DG!GM@  ,. < S-18109-929 ReproductiveK8 H & E Stain S-18109-92-059'Diagnosis: Endometrium with hyperplasiaClose-upDGNMC@  ,. < S-10098-96 ReproductiveW9 H & E Stain S-10098-96-019vDiagnosis: Complex hyperplasiaAnother example of complex hyperplasia showing highly branched glands. Note that the epithelium is stratified still and the nuclei are small, ovoid, and darkly staining.DGOOM@  ,. < S-10098-96 Reproductive: H & E Stain S-10098-96-029Diagnosis: Complex hyperplasiaClose-upDGFM>  *, : S-7999-93 Reproductive; H & E Stain S-7999-93-019NDiagnosis: Atypical hyperplasia of glands adjacent to normal appearing glandsOAtypical hyperplasia of glands (red arrow) adjacent to normal appearing glands (blue arrow). The normal appearing glands have a small, dark, ovoid nuclei and are contrasted with the larger, rounder nuclei of the atypical glands. Nucleoli can be found occasionally and there is more cytoplasm in the larger atypical epithelial glandsDG\M>  *, : S-7999-93 ReproductiveP< H & E Stain S-7999-93-029NDiagnosis: Atypical hyperplasia of glands adjacent to normal appearing glandsVClose-up with atypical hyperplasia (red arrow) and normal appearing gland (blue arrow)DGzM  8  $& 4 S-8124-93 Reproductive`=+Gross S-8124-93-01|8HDiagnosis: Uterus with endometrial carcinoma and left ovary with thecomaQUterus with endometrial carcinoma opened posteriorly and left ovary with thecoma.DG M!"8  $& 4 S-8124-93 Reproductive>vGross S-8124-93-028HDiagnosis: Uterus with endometrial carcinoma and left ovary with thecomafClose-up of uterus showing thickening of the endometrium caused by the carcinoma on the right (arrow).DGvM"!8  $& 4 S-8124-93 Reproductive?Gross S-8124-93-038NHDiagnosis: Uterus with endometrial carcinoma and left ovary with thecomaeClose-up of ovary showing enlargement and yellow color (indicating hormonal activity) by the thecoma.DGeM#>  *, : S-8124-93 Reproductive@ H & E Stain S-8124-93-04-9HDiagnosis: Uterus with endometrial carcinoma and left ovary with thecoma;Back-to-back glandular pattern of the endometrial carcinomaDG<5M$ >  *, : S-8124-93 ReproductiveA H & E Stain S-8124-93-059HDiagnosis: Uterus with endometrial carcinoma and left ovary with thecomaJClose-up showing lack of intervening endometrial stroma between the glandsDG*^M%@  ,. < S-14657-94 ReproductiveB H & E Stain S-14657-94-019 Diagnosis: Endometrial carcinomaXAnother endometrial carcinoma, this one showing glands with a cribriform pattern (arrow)DG@&M&@  ,. < S-14657-94 ReproductiveC H & E Stain S-14657-94-029 Diagnosis: Endometrial carcinomaClose-up showing anaplasiaDGM'~:  &( 6 S-15546-96l ReproductiveDGross S-15546-96-018QDiagnosis: Fallopian tube with hydrosalpinx; ovary showing yellow corpus luteum.Fallopian tube with hydrosalpinx (red arrow) and ovary showing distended tube with relative translucency of fluid and cut surface of ovary showing yellow corpus luteum (yellow arrow).DGM(8  $& 4 S-6310-72 ReproductiveEGross S-6310-72-012Diagnosis: Acute salpingitis2Uterus, fallopian tube with pyosalpinx, and ovary DGdM)8  $& 4 S-6310-72 ReproductiveFGross S-6310-72-026Diagnosis: Acute salpingitis.Close-up on hemorrhagic dilated tube and ovaryDG:M*8  $& 4 S-6310-72 ReproductiveG[Gross S-6310-72-038Diagnosis: Acute salpingitis]Drained tube with its contents in a petri dish. Note the yellow, opaque nature of the fluid.DG $M+8  $& 4 S-6310-72 Reproductive^HGross S-6310-72-04R4Diagnosis: Acute salpingitisxCross sections cut through fallopian tube with acute salpingitis. Note extensive thickening of the wall and purulence. DGFM,">  *, : S-6310-72 Reproductive6It H & E Stain S-6310-72-05.4LDiagnosis: Acute salpingitisCross section of fallopian tube with acute salpingitis, showing leukocytic infiltrate in the wall and essentially obliteration of the lumen.DGM->  *, : S-6310-72 ReproductiveJ[ H & E Stain S-6310-72-069Diagnosis: Acute salpingitis\Close-up showing dense leukocytic infiltrate into the wall, comprised mostly of lymphocytes.DGeM.>  *, : S-6310-72 Reproductive,K, H & E Stain S-6310-72-07-9Diagnosis: Acute salpingitiskAnother field of salpingitis showing dense infiltrate in the wall, comprised predominantly of plasma cells.DGM/Q>  *, : S-2114-90 ReproductiveLo H & E Stain S-2114-90-019!Diagnosis: Chlamydia trachomatis Another case of pelvic inflammatory disease showing fibrosis with fibroblasts obliterating the lumen of the fallopian tube. This particular case was caused by Chlamydia trachomatis.DGhM06  $& 2S-582-71g ReproductivehM Gross S-582-71-01Diagnosis: Ectopic pregnancyQFallopian tube with ectopic pregnancy showing focally hemorrhagic distended tube.DGWM16  $& 2S-582-71[ Reproductive[NGross S-582-71-026VDiagnosis: Ectopic pregnancyiCross sections cut through fallopian tube showing obliteration and distention of the lumen by hemorrhage.DGcM2<  *, 8S-582-71 Reproductive~O H & E Stain S-582-71-03-Diagnosis: Ectopic pregnancy9Chorionic villi and hemorrhage from ectopic implantation.DG'M3<  *, 8S-582-71G Reproductive^P H & E Stain S-582-71-049Diagnosis: Ectopic pregnancyClose-upDGgM4:  &( 6 S-17337-92@ ReproductiveeQGross S-17337-92-019Z.Diagnosis: Benign cystic teratoma of the ovary)Ovary enlarged by benign cystic teratoma.DGxM5:  &( 6 S-17337-92 ReproductiveR[Gross S-17337-92-028.Diagnosis: Benign cystic teratoma of the ovaryaBenign cystic teratoma of the ovary cut open, showing characteristic hair and sebaceous material.DGpM6:  &( 6 S-17337-92p ReproductiveiSoGross S-17337-92-0388.Diagnosis: Benign cystic teratoma of the ovaryClose-upDGj^M7@  ,. < S-13658-93 Reproductive[T H & E Stain S-13658-93-019.Diagnosis: Benign cystic teratoma of the ovary3Features resembling skin in benign cystic teratoma.DG?M8:  &( 6 S-13881-93 ReproductiveUGross S-13881-93-017Diagnosis: Dysgerminoma)Nodular, enlarged ovary with dysgerminomaDGJM9:  &( 6 S-13881-93 ReproductiveVGross S-13881-93-029 Diagnosis: Dysgerminoma@Cut surface showing dysgerminoma with characteristic nodularity.DG}wM:@  ,. < S-13881-93 ReproductiveW H & E Stain S-13881-93-039Diagnosis: Dysgerminoma.Nest of dysgerminoma cells in a fibrous stromaDG(M;$:  &( 6 S-14011-93 ReproductiveXGross S-14011-93-018,Diagnosis: Mucinous cystadenoma of the ovaryMucinous cystadenoma of the ovary, cut surface showing the smooth lining (wrinkles are present because the tissue was compressed) DG}M<:  &( 6 S-14011-93 ReproductiveYGross S-14011-93-028,Diagnosis: Mucinous cystadenoma of the ovary#Close-up showing lack of nodularityDG$M=@  ,. < S-14011-93 ReproductiveZ H & E Stain S-14011-93-039n,Diagnosis: Mucinous cystadenoma of the ovary@  ,. < S-14011-93 Reproductive[ H & E Stain S-14011-93-049h,Diagnosis: Mucinous cystadenoma of the ovaryIClose-up showing the characteristic mucinous cells without stratificationDGHM?:  &( 6 S-16649-92 Reproductive\Gross S-16649-92-019R5Diagnosis: Borderline serous cystadenoma of the ovarytBorderline serous cystadenoma of the ovary, showing external surface with small brown papillary excrescences (arrow)DG.#M@:  &( 6 S-16649-92 Reproductive]Gross S-16649-92-0295Diagnosis: Borderline serous cystadenoma of the ovaryClose-upDGgMA:  &( 6 S-16649-92 Reproductive^Gross S-16649-92-038&5Diagnosis: Borderline serous cystadenoma of the ovary>Cut surfaces of ovary, showing confluent nodular excrescences DG.MB:  &( 6 S-16649-92 Reproductive_Gross S-16649-92-0495Diagnosis: Borderline serous cystadenoma of the ovaryClose-upDG,4MC)@  ,. < S-16649-92 Reproductive` H & E Stain S-16649-92-0595Diagnosis: Borderline serous cystadenoma of the ovaryxBorderline serous cystadenoma with the characteristic large dilated papillae with tufting (micropapillary configuration)DGm^MD@  ,. < S-16649-92 Reproductivea H & E Stain S-16649-92-0695Diagnosis: Borderline serous cystadenoma of the ovary Close-up DGME@  ,. < S-16649-92 Reproductiveb H & E Stain S-16649-92-0795Diagnosis: Borderline serous cystadenoma of the ovary9Lymph node with subcapsular invasion by the tumor (arrow)DGSMF6  $& 2S-273-67 ReproductivecGross S-273-67-018'Diagnosis: Papillary cystadenocarcinomafEnlarged cystic ovary with solid nodules on its external surface cause by papillary cystadenocarcinomaDGrMG6  $& 2S-273-67 ReproductivedGross S-273-67-029'Diagnosis: Papillary cystadenocarcinomaClose-up of solid nodules DGMH6  $& 2S-273-67 ReproductiveeGross S-273-67-037,'Diagnosis: Papillary cystadenocarcinomauOpened ovary showing multiple internal papillary nodules characteristic of papillary cystadenocarcinoma of the ovary DGMI6  $& 2S-273-67 ReproductivefGross S-273-67-049'Diagnosis: Papillary cystadenocarcinomaClose-upDG MJ@  ,. < S-13305-94 Reproductiveg H & E Stain S-13305-94-019x'Diagnosis: Papillary cystadenocarcinoma;Papillae of cystadenocarcinoma with finger-like projectionsDGF MK@  ,. < S-13305-94 Reproductiveh H & E Stain S-13305-94-029'Diagnosis: Papillary cystadenocarcinoma7Close-up showing crowded, disorganized papillary glandsDG)2ML@  ,. < S-13305-94 Reproductivei H & E Stain S-13305-94-039'Diagnosis: Papillary cystadenocarcinoma:Glands invading the stroma in papillary cystadenocarcinomaDG0MM@  ,. < S-13305-941 Reproductiveoj\ H & E Stain S-13305-94-049'Diagnosis: Papillary cystadenocarcinomaClose-upDGk1MN>  *, : S-3314-93 Reproductivek H & E Stain S-3314-93-019'Diagnosis: Papillary cystadenocarcinomaJPsammoma bodies frequently found in papillary cystadenocarcinomas (arrows)DGMO:  &( 6 S-16334-94 Reproductive8lGross S-16334-94-018&Diagnosis: Mucinous cystadenocarcinomaCut surface of ovary with mucinous cystadenocarcinoma showing a partially smooth lining to the right and solid nodule to the left. DG9MP:  &( 6 S-16334-94 ReproductiveSmGross S-16334-94-029&Diagnosis: Mucinous cystadenocarcinoma Close-up DGUfMQ:  &( 6 S-16334-94 ReproductivenGross S-16334-94-03!h&Diagnosis: Mucinous cystadenocarcinoma3Mucinous fluid from contralateral tumor - 6,350 mlsDGMR@  ,. < S-16334-94 Reproductiveo H & E Stain S-16334-94-049&Diagnosis: Mucinous cystadenocarcinomaEMucinous cystadenocarcinoma showing stratification and complex glandsDGfMS@  ,. < S-16334-94 Reproductivep H & E Stain S-16334-94-059v&Diagnosis: Mucinous cystadenocarcinoma'Back-to-back pattern of atypical glandsDGjxMT@  ,. < S-16334-941 Reproductive^q H & E Stain S-16334-94-069&Diagnosis: Mucinous cystadenocarcinomaTumor in ovarian tissueDGMU@  ,. < S-16334-94d Reproductive[r H & E Stain S-16334-94-079&Diagnosis: Mucinous cystadenocarcinoma,Vascular (lymphatic) invasion by tumor cellsDGuMV8  $& 4 S-6494-94 ReproductivesGross S-6494-94-019T>Diagnosis: Bilobed placenta with velamentous insertion of cord3Bilobed placenta with velamentous insertion of cordDGJMW:  &( 6 S-15505-93 Reproductive$t_Gross S-15505-93-019>Diagnosis: Hydatidiform mole@Curettings with hydatidiform mole showing vesicular abnormality DGYMX:  &( 6 S-15505-93 ReproductiveuGross S-15505-93-028Diagnosis: Hydatidiform mole Close-up DGmMY@  ,. < S-15505-93L Reproductivev H & E Stain S-15505-93-039zDiagnosis: Hydatidiform moledHydropic swelling of the villi with inadequate vascularization characteristic of a hydatidiform moleDGGVMZ>  *, : CC-144-84 Reproductivew H & E Stain CC-144-84-019Diagnosis: Normal breast%Normal breast from a 10 year old girlDGeM[<  *, 8CC-50-87 Reproductivex H & E Stain CC-50-87-019Diagnosis: Normal breast %Normal breast from a 13 year old girlDG-M\:  &( 6 CC-162-88 ReproductiveyAutopsy CC-162-88-019Diagnosis: Normal breast%Normal breast from a 21 year old ladyDGMPM]>  *, : CC-162-88 Reproductivez H & E Stain CC-162-88-029Diagnosis: Normal breast%Normal breast from a 21 year old ladyDGL|M^>  *, : CC-162-88 Reproductive{ H & E Stain CC-162-88-039Diagnosis: Normal breast%Normal breast from a 21 year old ladyDGCM_:  &( 6 A-150CC-68 Reproductive|Gross A-150CC-68-01$B&Diagnosis: Breast from a pregnant lady.Breast tissue from a 19 year old pregnant ladyDGfM`@  ,. < A-150CC-68 Reproductive} H & E Stain A-150CC-68-023&Diagnosis: Breast from a pregnant lady.Breast tissue from a 19 year old pregnant ladyDGl$Ma@  ,. < A-150CC-68 Reproductive~ H & E Stain A-150CC-68-039&Diagnosis: Breast from a pregnant lady.Breast tissue from a 19 year old pregnant ladyDGMb8  $& 4 S-2139-61 ReproductiveGross S-2139-61-018HDiagnosis: Fibrocystic changes$Fibrocystic changes in breast tissueDG+Mc>  *, : S-2139-61 Reproductive H & E Stain S-2139-61-027tDiagnosis: Fibrocystic changes^Fibrocystic changes: Left - fibrosis Right - cystic changesDG  *, : S-6813-84 Reproductive H & E Stain S-6813-84-029Diagnosis: Sclerosing adenosisSclerosing adenosisDG Mf>  *, : S-6813-84 Reproductive H & E Stain S-6813-84-039Diagnosis: Sclerosing adenosisSclerosing adenosisDG};Mg6  $& 2S-120-93 ReproductiveGross S-120-93-018Diagnosis: Fibroadenoma$Fibroadenoma from a 17 year old girlDG}Mh6  $& 2S-120-93 ReproductiveGross S-120-93-028Diagnosis: Fibroadenoma$Fibroadenoma from a 17 year old girlDGNMi<  *, 8S-120-93 Reproductive H & E Stain S-120-93-039Diagnosis: Fibroadenoma$Fibroadenoma from a 17 year old girlDGzMj:  &( 6 S-12268-93 ReproductiveGross S-12268-93-018Diagnosis: Phylloides tumor(Phylloides tumor from a 50 year old ladyDGIMk@  ,. < S-12268-93 Reproductive H & E Stain S-12268-93-029tDiagnosis: Phylloides tumor(Phylloides tumor from a 50 year old ladyDG Ml@  ,. < S-12241-91 Reproductive H & E Stain S-12241-91-019-Diagnosis: Intraductal carcinoma, comedo-type"Intraductal carcinoma, comedo-typeDGzMm>  *, : S-9585-92 Reproductive  H & E Stain S-9585-92-01"9PDiagnosis: Infiltrating intraductal carcinoma, cribiform type and scirrhous type&Intraductal carcinoma - cribiform typeDGMn>  *, : S-5538-86 Reproductive H & E Stain S-5538-86-019$Diagnosis: Lobular carcinoma in-situLobular carcinoma in-situDGLMo8  $& 4 S-9585-92 ReproductiveGross S-9585-92-024PDiagnosis: Infiltrating intraductal carcinoma, cribiform type and scirrhous type3Infiltrating intraductal carcinoma - scirrhous typeDGr"Mp>  *, : S-9585-92 Reproductive H & E Stain S-9585-92-039PDiagnosis: Infiltrating intraductal carcinoma, cribiform type and scirrhous type3Infiltrating intraductal carcinoma - scirrhous typeDG#Mq8  $& 4 S-7955-92 ReproductiveGross S-7955-92-01X4t)Diagnosis: Infiltrating lobular carcinomaInfiltrating lobular carcinomaDGMr>  *, : S-7955-92 Reproductive Y H & E Stain S-7955-92-028)Diagnosis: Infiltrating lobular carcinomaInfiltrating lobular carcinomaDGAMs6  "$ 2 S-3028-86Renal3 H & E Stain S-3028-86-03k3 :Diagnosis: Transitional cell carcinoma of the renal pelvis\Photomicrograph of the tumor showing (finger-like) papillary transitional cell carcinoma.DGkMt8   &( 4A-118-60Cardiovascular N%Gross A-118-60-01%9Diagnosis: Primary myxoma of the left atrium of the heart Atrial myxomaDGEMu8   &( 4A-118-60zCardiovascularOGross A-118-60-02#d9Diagnosis: Primary myxoma of the left atrium of the heart"Opened heart with an atrial myxomaDGu^Mv<   ""(* 8 S-1393-85GastrointestinalGross S-1393-85-01!4Diagnosis: Adenoid cystic carcinoma with metastases 1Submandibular gland with adenoid cystic carcinomaDGMwB   "".0 > S-1393-85GastrointestinalL H & E Stain S-1393-85-02;94Diagnosis: Adenoid cystic carcinoma with metastases 1Adenoid cystic carcinoma with perineural invasionDGMx<   ""(* 8 S-1393-85GastrointestinalGross S-1393-85-0384Diagnosis: Adenoid cystic carcinoma with metastases 3Wedge of lung - metastatic adenoid cystic carcinomaDG\@My<   ""(* 8 S-1393-85Gastrointestinal<Gross S-1393-85-04^74Diagnosis: Adenoid cystic carcinoma with metastases Cut surface of lung nodule DGm@MzB   "".0 > S-3955-94GastrointestinalP H & E Stain S-3955-94-01g9 HDiagnosis: Barrett's esophagus with severe dysplasia and adenocarcinoma ?Barrett's esophagus with severe dysplasia - biopsy of esophagusDGk}OI *  @̀рL׀a܀ )k*09IUMd\ i os~| 6{wÀƀ̀΀F=GQрJ=Ҁ]^Ӏ[@ԀBFՀK?րDU׀EM؀m@ـQBڀ@HۀRL܀EE݀E5ހFF߀FAAIIYbXBSzSa5==C^@AHXQ@;F=IQC<<@KPIlD?S i c I R R Q \ V B @ D D     E M |  Q  Z  / ' " %5 'W ) + - 0" 1 2 4 5p 7 ? B, E G] I Ka P Te Tl Ue U^ Vj Vt Wl WX XV X Yu Y Zh [ \ ]y ]h ^u ^r _n _n ` a b cs c dX eo ez f] f] g{ g h it i j k l ma n~ nc o ox p} ph qv qp rG s9 u w y { j C F V F C F F E H d Z K   p F I w :  | J t y Y  K ` ' R P Q `  ? C  U X U n G G @ p X M fDG&M    S-7787-72 This patient had numerous admissions to the hospital. His first was at the age of 10 and at this time he had a tonsillectomy and adenoidectomy. The patient was next admitted to Memorial Medical Center at the age of 33 with hemorrhoids; a hemorrhoidectomy was performed. At this time, a family history of polycystic kidney disease was noted and an intravenous pyelogram had evidence of polycystic kidney disease. At this time, a blood pressure was 106/80 mmHg. He was re-admitted at the age of 34 with his first episode of hematuria. The hematocrit at this time was 47% and the hemoglobin 15.4 gm/dl. A BUN was 22.5 mg/dl. A urine specimen had 10 mg/dl albumin and 25-30 white blood cells. The blood pressure was 116/80 mmHg. He was re-admitted at the age of 39, again with hematuria. The blood pressure was 130/70 mmHg. The pyelogram showed definite progression of the disease since the last admission. The urine specimen had 280 mg/dl of albumin and 5-6 white blood cells. The BUNs were 18.2 and 22.3 mg/dl. A creatinine level was 1.4 mg/dl. A urine culture was negative. He was again admitted at the age of 42 with a history of generalized aching with an elevated uric acid. He had been on colbenemid. His blood pressure was 140/96 mmHg, the BUN 33 mg/dl and creatinine 3.5 mg/dl. Uric acid was elevated to 7.7 mg/dl. The hemoglobin was 16 gm/dl. Massively large kidneys were clearly apparent. At the age of 44, he complained of increase in fatigue, history of an upper respiratory infection and history of urinary tract infection. Hematuria was noted and hypertension was present. There was recent evidence of phlebitis. A blood pressure at the time of hospitalization was not elevated. A creatinine clearance was 17-19 ml. per min. The BUN was 70 mg/dl, the creatinine 6.6 mg/dl and the hemoglobin 14.1 mg/dl. He was admitted two months later with left abdominal pain and apparent swelling in the left flank. The hypertension had been controlled by Aldomet. The BUN was 49 mg/dl, the creatinine 7.8 mg/dl and the hemoglobin 12.6 gm/dl. The hematocrit was 38%. There was grade II hypertensive retinopathy and a blood pressure was 160/100 mmHg. The patient was admitted a month later in congestive heart failure. A BUN was 51 mg/dl and a creatinine 9.2 mg/dl. The hemoglobin was 13.6 gm/dl. Hemodialysis was done. Three months later he was admitted for creation of an AV fistula for the purposes of dialysis. The BUN was 93 mg/dl and the creatinine was 11.7 mg/dl. The hemoglobin was 12.6 gm/dl. Approximately one year later at the age of 45 he complained of moderately severe pain in the left hypochondrium. At this time he had a bilateral nephrectomy. Following the nephrectomy, multiple liver abscesses occurred and were drained. The family history was positive for polycystic disease. The father and two brothers died of polycystic kidney disease. Two sisters had the disease. The patient had four children, all without known polycystic disease. This patient ultimately died at the age of 51. A renal transplant had failed. The patient also had a history of convulsive episodes with a marked sensitivity to anticonvulsive agents making the convulsive episodes difficult to control. At autopsy, there was fairly severe atherosclerosis of the aorta. There was focal moderate, moderately stenosing atherosclerosis of the coronary arteries with a complete occlusion of the proximal portion on the circumflex branch. Describe the abnormal features present in these kidneys. Adult polycystic kidney diseaseDG;M    S-6342-72>The patient was a 73-year-old gentleman with a history of weakness and profound anemia. An intravenous pyelogram had a filling defect in the upper pole of the left kidney. The clinical diagnosis was anemia, cause undetermined, and a possible cancer of the left kidney. A number of sophisticated radiologic tests, including angiography, were done and these tests supported the possible diagnosis of a renal tumor. Therefore, a left nephrectomy was carried out. A 700 gram mass of tissue, including a kidney and surrounding perinephric fat, was received in the surgical pathology laboratory. A large 6 cm. unilocular cystic region was noted at the upper pole somewhat posteriorly. Thin fluid was present in the lumen. An interesting and unusual feature of the lining of the cyst was thin flakes of calcium in the cyst wall. There was no evidence of tumor. This is another instance where a solitary cyst was misdiagnosed. Note that small plaques of calcium can be seen on the cyst lining. It was these plaques of calcium that were partially responsible for the misdiagnosis. &Large solitary cyst of the left kidneyDGMo    S-14511-90nMinimal change glomerulonephritis. The patient was a 58-year-old Caucasian lady who was in good health until 6 months prior to admission at which time she became tired and during the following months progressively became more tired. She went to see her physician and he discovered that there was a large amount of protein in her urine. She was referred to a nephrologist and on several occasions he quantitated that there was greater than 3 gm/24 hours in her urine. On questioning, she did state that at the end of the day her ankles would swell. She was admitted to the hospital for a renal biopsy to determine the etiology for her persistent proteinuria. Physical Examination Vital signs: blood pressure 120/75 mmHg, respiration 12/min. and regular, pulse 22/min. and regular, temperature 98.6F. Chest: clear to auscultation and percussion. Heart: PMI in 5th intercostal space midclavicular line, systolic click with Grade 1/6 systolic present at the upper left sternal border. Abdomen: flat without organomegaly. Extremities: no evidence of edema. Hospital Course A renal biopsy was performed and on the basis of light microscopy and special studies, a diagnosis of minimal change glomerulonephritis was made. The patient was discharged that day and was scheduled to be seen by the nephrologist the following week. Minimal change disease or lipoid nephrosis more commonly occurs in children than adults. It is the most common cause of nephrotic syndrome in children. In both children and adults the disease typically responds to steroid therapy. The only finding on renal biopsy, as in this case, is fusion of the foot processes. The prognosis for this patient is very good. gWBC 5.6 k/cu.mm. Hemoglobin 13 gm/dl Hematocrit 38% Differential Normal BUN 27 mg/dl Creatinine 0.8 mg/dl Cholesterol 204 mg/dl Creatinine clearance 91 mm/min. Serum protein 6.7 gm/dl Serum albumin 4.4 gm/dl ANA Negative Anti-DNA Negative C4 28 mg/dl C3 126 mg/dl Urine Studies Protein 3 gm/24 hrs. !Minimal change glomerulonephritisDGuIM     S-10023-90. Membranous glomerulonephritis. The patient was a 74-year-old Caucasian gentleman who was in good health until 8 months prior to admission when he developed marked swelling of his lower extremities. He was seen by his family physician and was found to have 4+ proteinuria on urinalysis. He was started on diuretic therapy. His edema, however, continued to become more severe, he started to feel his abdomen was enlarging and he was having difficulty breathing. An ultrasound examination of the abdomen had evidence of ascites and normal sized kidneys without evidence of hydronephrosis. He was admitted to the hospital for elective renal biopsy to establish the etiology for his persistent edema and marked proteinuria (nephrotic syndrome). Past Medical History The patient had an 80 pack/year smoking history. Physical Examination Vital signs: blood pressure 130/80 mmHg, pulse 72/min., respiration 18/min., temperature 37.2C., pale skin. HEENT: pale conjunctiva. Chest: increased AP diameter, clear to auscultation and percussion, breath sounds somewhat diminished. Heart: PMI not detected, heart sounds diminished in intensity, no murmurs or gallops. Abdomen: distended and tense, no organomegaly. Extremities: 2+ pitting ankle and pedal edema, sacral edema. Hospital Course On the day after admission a renal biopsy was performed and based upon the light microscopy findings and special studies, a diagnosis of membranous glomerulonephritis was made. There were no complications and the patient was discharged 24 hours after admission and is currently being followed by a local nephrologist. Membranous glomerulonephritis is the most common cause of the nephrotic syndrome in adults. Hematuria may be present in some of these patients, as in this case. The kidney injury is secondary to deposition of circulating immune-complexes. In the vast majority of patients the source of the antigen is not known (idiopathic membranous glomerulonephritis). Similar changes can occur in association with known disorders or etiologic agents including malignancies, autoimmune diseases, exposure to drugs or poisons, infections, and metabolic diseases. This patient was considered to have idiopathic membranous glomerulonephritis. The course is typically unpredictable but approximately one-half of these patients will develop end-stage renal disease in an unpredictable span of two to five years. The fact that the BUN and creatinine were markedly increased and this patients edema was progressively becoming more severe would indicate a rapid progression of his disease. With further reduction of functioning renal ability, the patient will become a candidate for chronic dialysis. WBC 9.9 k/cu.mm. Hemoglobin 10.4 gm/dl Hematocrit 30% Differential Normal BUN 67 mg/dl Creatinine 2.8 mg/dl Serum protein 4.2 gm/dl Serum albumin 0.8 gm/dl Cholesterol 375 mg/dl Creatinine clearance 43 mm/min. 24 hour protein 18.2 grams Urinary sedimentation 10-15 red cells per high power field 3-5 white cells per high power field Bence-Jones protein NegativeMembranous glomerulonephritisDGM~    A-205-75lDiffuse proliferative glomerulonephritis post-infectious, (non-streptococcal). This 55-year-old Caucasian gentleman presented with fever, malaise, and anorexia. Six blood cultures were positive for Staphylococcus aureus. An echocardiogram detected large vegetations on the aortic valve. He had suffered from rheumatic fever in childhood. In spite of multiple antibiotic therapy, the patient developed many embolic complications to kidney and brain. The progressive oliguria required hemodialysis. The previously controlled diabetes was complicated by ketoacidosis. Note the marked hypercellularity of the glomerulus with normal capillary loop walls. The relevant laboratory findings included Staphylococcus aureus in blood cultures. The white blood cell count was 25,900 with 16 bands, 75 segs, 8 lymphs, and 1 mono. The hemoglobin was 11.1 mg/dl and the hematocrit 33%. The BUN was 109 mg/dl and creatinine 7.5 mg/dl. The serum electrolytes revealed a sodium of 117 mEq/L, potassium 6.3 mEq/L, chlorides 86 mEq/L, and total CO2 10 mmol/L. The serum calcium was 5.8 gm/dl. The serum phosphate was 8.2 mg/dl. The total protein was 6.7 gm/dl, the albumin, 2.12 gm/dl; alpha-2-globulin, 0.44 gm/dl; alpha-2 globulin, 0.84 gm/dl; beta globulin, 0.52 gm/dl; and gamma globulin, 2.78 gm/dl.A-96-63The patient was a 52-year-old Caucasian lady diabetic who died of a myocardial infarction. There is a thrombus in the opened coronary artery. The massive thickening of the coronary artery wall is due to atherosclerosis. There is a discrete, well-delineated, yellow region, in the myocardium with peripheral hemorrhage. This is a classic gross appearance of a recent myocardial infarct. Typical coagulation necrosis is present microscopically. Also there is liquefaction necrosis.1Recent infarct of the left ventricle of the heartDGaXMSA-25-72This 66-year-old lady had a sudden onset of severe abdominal pain. She died shortly thereafter. At autopsy there was a massive hemorrhagic infarction of virtually the entire jejunum and ileum. These infarcts are typically hemorrhagic and the prognosis is usually very poor.Infarction of the bowelDGMqA-92-61MThis 46-year-old gentleman had a history of severe ischemic heart disease and myocardial insufficiency. He also had recurrent episodes of backward heart failure. An x-ray had evidence of severe cardiac enlargement. This appearance of chronic passive congestion of the liver is due to severe dilatation of the central veins and central sinusoids which contrast rather markedly with the more uncongested peripheral portions of the lobule. The liver tissue itself often is paler due to associated fatty changes. This gross appearance has been likened to the cut surfaces of whole nutmeg.Laboratory tests included the following: chloride 92 mmol/L, sodium 129 mmol/L, total bilirubin 3.25 mg/dl, and BUN 60 mg/dl. Terminally, lethargy and confusion occurred and he died on the 33rd hospital day.'Chronic passive congestion of the liverDGGM     S-4763-73This patient was a 69-year-old lady with a change in the past 18 months which was described as the blahs. Apparently this meant weakness, lethargy and fatigue. Two weeks prior to hospital admission she discovered hard, mildly tender regions in both temporal areas. She complained of mild but constant headaches. She also noted a 10-pound weight loss over one year and slight anorexia. There was a history of arthralgia of long duration. Multiple firm, mildly tender vessels without pulsations were demonstrable in the temporal region. The hemoglobin was 11 grams, the hematocrit was 34% and the sedimentation rate 56 mm/hr. A left temporal artery biopsy was performed. The lumen of the biopsied temporal artery has a small crescent-shaped slit near the center. Note the intimal proliferation. Note the foci of rather eosinophilic amorphous material in the media and the giant cells in the media. Also note the disruption of the usual medial architecture. Note also the intimal fibrosis and granulomatous inflammation with giant cells. Also present are eosinophilic areas of necrosis. The sedimentation rate is important clinically to help establish the diagnosis. Giant cell or temporal arteritisDG^M!    CC-49-64The patient was a 56-year-old gentleman who committed suicide by inhaling carbon monoxide. A fibrocollagenous cap and the zone of lipid debris are visible.1Uncomplicated atherosclerotic plaques (atheromas)DG}M"    A-158-67@mThe patient was a 33-year-old Caucasian diabetic gentleman who had had diabetes mellitus since the age of 16.DSevere severely obstructing atherosclerosis of the coronary arteriesDG}M# A-68-58This 47-year-old Caucasian house painter had been admitted to St. John's Hospital the previous year because of fatigue. At this time a diagnosis of essential hypertension was made. In the following year he was admitted to Memorial Medical Center because of a convulsion. The blood pressure on admission was 240/130 mmHg and the BUN was 72 mg/dl. A hemoglobin was 11.9 gm/dl and a hematocrit 36%. The patient was discharged with diagnoses of severe essential hypertension, ischemic heart disease and anasarca. Approximately a month later, he was readmitted to the hospital and at this time he had a BUN of 82 mg/dl. The final admission occurred the following month because of gradually increasing dyspnea and anasarca. On admission the BUN was 85 mg/dl. Death occurred on the 16th hospital day. An autopsy was performed. The body was that of a well-developed, somewhat slender Caucasian gentleman. There was no unusual external features. There was mild pitting edema of the lower extremities. The abdominal cavity contained 273 ml of thin cloudy yellow fluid. The left pleural cavity contained 1,520 ml of clear light yellow fluid and the right pleural cavity 240 ml. of similar fluid. There were fibrous bands between the parietal and visceral pleura bilaterally. The aorta contained moderate, rather bright orange-yellow plaquing. On surfaces made by cutting the lungs, the tissue was much redder than normal and also had a brown appearance. On opening the pericardium, a shaggy exudate covered the surfaces of both the visceral and parietal pericardium and there was blood in the pericardial sac. There was no evidence of a myocardial rupture. The coronary arteries had mild yellow plaquing. The right ventricle measured 1 cm. in thickness and the left ventricle 2.2 cm. in thickness. The left ventricular chamber was also dilated. The heart weighed 660 grams. The spleen was mildly enlarged and weighed 310 grams. The liver weighed 2700 grams and had marked nut-megging. Pictures are of the heart (compared to a normal heart), bread and butter pericarditis, hyaline, hyperplastic arteriosclerosis, and fibrinoid necrosis of arterioles of renal blood vessel, and the aorta. TSevere hypertensive heart disease and severe arteriolonephrosclerosis - cardiomegalyDGX]M$    A-179-64&The patient was a 58-year-old gentleman who was admitted to the hospital because of right-sided hemiplegia and aphasia with an onset 3 days prior to hospital entry. The clinical diagnosis was thrombosis of the left middle cerebral artery. A Grade II diastolic murmur was present at the left sternum in the second to fourth interspace spaces. His pulse was grossly irregular. He died on the 6th hospital day. This patient had a history of severe pneumonia as a child, measles at the age of 3 or 4 years, and scarlet fever at the age of 6. He also indicated that a heart leakage was discovered while a freshman in college. A diagnosis of chronic rheumatic heart disease with mitral insufficiency and auricular fibrillation was made at that time. Digitalis was administered to control his arrhythmia.4Mitral stenosis - chronic rheumatic valvular diseaseDGpM%r    A-210-71&The patient was a 70-year-old lady with a history of numerous hospital admissions over a 4 year period for congestive heart failure due to rheumatic disease with mitral stenosis. She had been suspected of having a possible pulmonary embolus and also a myocardial infarct. On the day of her last hospital admission she suddenly lost her speech and developed a right hemiplegia. Laboratory and x-ray studies were normal. Her condition stabilized and physical therapy was begun. On the day of death she suddenly developed severe respiratory distress and died. The cause of death determined at autopsy was bronchopneumonia. The maximum thickness of the opened right ventricle is 1 cm. The right kidney contains an area of an old infarct. Changes of chronic passive congestion are present in the liver."Chronic rheumatic valvular diseaseDGH^M&    CC-56-71The patient was a 70-year-old gentleman who died suddenly and unexpectedly at home. The coroner order an autopsy. He had no significant past medical history. Calcific aortic stenosisDGnM)    CC-124-90kThe patient was a 70-year-old Caucasian gentleman who was found dead in his bed early in the morning. The decedent had never been to see a physician. An autopsy was performed. Autopsy Diagnoses 1. Large old myocardial infarction involving the major portion of the posterior wall and lateral wall of the left ventricle. 2. Atherosclerosis of the coronary arteries with: a. Severe, virtually completely occlusive atherosclerosis of the right coronary artery with a large atheroma severely narrowing the lumen 1 cm. from the origin. b. Moderate, moderately stenosing atherosclerosis of the left coronary artery. c. Severe, severely stenosing atherosclerosis of the anterior descending branch of the left coronary artery. d. Severe, severely stenosing atherosclerosis of the circumflex branch of the left coronary artery. 3. Heart weight 650 grams with left ventricular hypertrophy (2 cms.). 4. Severe atherosclerosis of the aorta. 5. Bilateral pulmonary artery congestion and edema. 6. Arteriolonephrosclerosis and focal chronic pyelonephritis of the kidneys. The marked cardiac hypertrophy was most likely the result of chronic systemic hypertension. The cardiac enlargement together with severe coronary atherosclerosis predisposed this gentleman to sudden unexpected death. We often come across coroners cases in which the decedent has no known medical history.@Chronic ischemic heart disease with an old myocardial infarctionDGEM*    CC-82-69xThis 87-year-old lady was found dead at home. There was no known past medical history. The coroner ordered an autopsy..Huge syphilitic aneurysm of the thoracic aortaDGVM+CC-7-57The patient was a 65-year-old Black gentleman who was found dead in bed at home. The past medical history was unreliable. The body was referred to Memorial Medical Center by the coroner's office. Severe hypertrophy of the heart (1023 grams) was present as well as tuberculous pericarditis. There was considerable adherence of the pericardium to surrounding structures. The markedly enlarged heart with hypertrophy and dilatation of the ventricular chambers suppo